[:pb]Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR) Modeling of Amino–Imino Tautomers[:]
[:pb]Authors: Bispo, M. L. F.; Lima, C. H. S.; Cardoso, L. N. F.; Candéa, A. L. P.; Bezerra, F. A. F. M.; Lourenço, M. C. S.; Henriques, M. G. M. O.; Alencastro, R. B.; Kaiser, C. R.; De Souza, M. V. N.; Albuquerque, M. G. Source: Pharmaceuticals, v. 10, p. 52-68, 2017 Publisher: MDPI Abstract […]
[:pb]Microwave-Assisted Synthesis of Quinoxalines – A Review[:]
[:pb]Authors: De Souza, M. V. N.; Gomes, C. R. B.; Facchinetti, V. Source: Current Microwave Chemistry, v. 04, p. 277-286, 2017 Publisher: Bentham Science Abstract Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times […]
[:pb]Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzylidene-N-methyl-2-(thiophen-2-yl)acetohydrazides[:]
[:pb]Authors: Cardoso, L. N. F.; Nogueira, T. C. M.; Kaiser, C. R. ; Wardell, J. L.; De Souza, M. V. N.; Harrison, W. T. A. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 73, p. 1636-1641, 2017 Publisher: Crystallographic Communications Abstract The syntheses and crystal structures of (E)-N′-(3-cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H13N3OS, (I), and (E)-N′-(4-methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H16N2O2S, (II), with different substituents in […]
[:pb]N-acylhydrazones containing thiophene nucleus: a new anticancer class[:]
[:pb]Authors: Cardoso, L. N. F.; Nogueira, T. C. M.; Rodrigues, F. A. R.; Oliveira, A. C. A.; Luciano, M. C. S.; Pessoa, C.; De Souza, M. V. N. Source: Medicinal Chemistry Research, v. 26, p. 1605-1608, 2017 Publisher: Springer Abstract In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven […]
[:pb]Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure[:]
[:pb]Authors: Pinto, Ligia S.; De Souza, M. V. N.; Kaiser, C. R. Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017 Publisher: Bentham Science Abstract Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report […]
[:pb]N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity[:]
[:pb]Authors: Barbosa-Lima, G. ; Pinto, L. S.; Kaiser, C. R.; Wardell, J. L.; De Freitas, C. S.; Vieira, Y. R ; Marttorelli, A.; Neto, J. C.; Bozza, P. T.; Wardell, S. M. S. V.; De Souza, M. V. N.; Souza, T. M. L. Source: European Journal of Medicinal Chemistry, v. 127, p. 434-441, 2017 Publisher:Science […]
[:pb]Sonochemistry as a General Procedure for the Synthesis of Coumarins¬, Including Multigram Synthesis[:]
[:pb]Authors: Pinto, L. S.; De Souza, M. V. N. Source: Synthesis-Stuttgart, v. 49, p. 2677-2682, 2017 Publisher: Thieme Connect Abstract This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very […]
[:pb]2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine[:]
[:pb]Authors: Barbosa-Lima, G.; Moraes, A. M.; Araújo, A. S. ; Da Silva, E. T.; De Freitas, C. S.; Vieira, Y. R.; Marttorelli, A.; Neto, J. C.; Bozza, P. T.; De Souza, M. V.N. ; Souza, T. M. L. Source: European Journal of Medicinal Chemistry, v. 127, p. 334-340, 2017 Publisher: Science Direct Abstract Zika virus (ZIKV), […]
[:pb]Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives[:]
[:pb]Authors: Nogueira, T. C. M.; Pinheiro, A. C.; De Souza, M. V. N.; Baddeley, T. C.; Wardell, J. L.; Wardell, S. M. S. V. Source: Journal of Molecular Structure (Print), v. 1128, p. 579-589, 2017 Publisher: Science Direct Abstract The crystal structures of four 1-aryl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives, 2, are reported: [aryl = 3-ClC6H4: 2a; 2-HOC6H4:2b;2,3-(HO)2C6H3: 2c; and 3,4-(MeO)2C6H3: 2d] The compounds, 2, were […]
[:pb]Crystal structures and Hirshfeld surface analyses of halogen substituted azine derivatives, 1,4-bis(halophenyl)-2,3-diazabuta-1,3-dienes[:]
[:pb]Authors: Correia, N. R. L.; Nogueira, Thais C. M.; Pinheiro, A. C.; De Souza, M. V. N.; Gomes, L. R.; Low, J. N. ; Wardell, J. L.; Wardell, S. M. S. V. Source: Zeitschrift Für Kristallographie – Crystalline Materials, v. 233, p. 135-143, 2018 Publisher: De Gruyter Abstract The crystal structures and Hirshfeld surface analyses are reported, from […]
[:pb]Evaluation of 1,3-benzoxathiol-2-one derivatives as potential antifungal agentes[:]
[:pb]Authors: Terra L.; Chazin E. L.; Sanches, P. S., Saito, M.; De Souza, M. V. N.; Gomes, C. R. B.; Wardell, J. L.; Wardell, S. M. S. V.; Sathler, P. C.; Silva, G. C. C.; Lione, V. O.; Kalil, M.; Joffily, A.; Castro, H. C.; Vasconcelos, T. R. A. Source: Medicinal Chemistry, v. 14, p. […]
