Search
Close this search box.

A new and potent class of quinoline derivatives against cancer

Authors: Bispo, M.L.F.; Alcântara, C.C.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Kaiser, C.R.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N.


Abstract

A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in μg/cm3. These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 μg/cm3. These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.
Keywords: Drug research, Antitumor agents, Heterocycles, Hydrazones, Quinoline compounds Document Type: Research Article DOI: https://doi.org/10.1007/s00706-015-1570-0 Publication date: 16 de Setembro de 2015

Compartilhar publicação

Facebook
Twitter
Email
LinkedIn
WhatsApp

Deixe seu comentário

Compartilhar

Sobre a SSCDT

Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.

posts Recentes