Authors: Bispo, M.L.F.; Alcântara, C.C.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Kaiser, C.R.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N.
Source: Monatshefte fur Chemie, v. 146, p. 2041-2052, 2015
Publisher:
Abstract
A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in μg/cm3. These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 μg/cm3. These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.Keywords: Drug research, Antitumor agents, Heterocycles, Hydrazones, Quinoline compounds Document Type: Research Article DOI: https://doi.org/10.1007/s00706-015-1570-0 Publication date: 16 de Setembro de 2015
