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[:pb]Experimental and computational evidence for stabilising parallel, offset π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interactions in acetohydrazide derivatives[:]

[:pb]Authors: Tan, S. L. ; Cardoso, L. N. F. ; De Souza, M. V. N. ; Wardell, S. M. S. V. ; Wardell, J. L. ; Tiekink, E. R. T.
Source: CrystEngComm, v. 24, p. 962-974, 2022
Publisher: Royal Society of Chemistry


Abstract

Parallel, offset π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–N[double bond, length as m-dash]C(H)Ph, along with more conventional non-covalent interactions. All notable interactions were analysed using Hirshfeld surface analysis, NCI plots and QTAIM analysis. The π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interactions, whereby the [N with combining low line](H) atom lies over the ring centroid and the N and C atoms on either side of the [N with combining low line](H) atom closely overlay the 1,3-carbon atoms of the phenyl ring, are shown to be attractive. Theory suggests the energy of association provided by the π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interaction to the molecular packing to be about 15 kJ mol−1, a value similar to that provided by similarly oriented benzene and pyridine rings. A survey of related structures in the literature suggests that comparable interactions occur in approximately 5–6% of crystals where they can potentially occur.


Document Type: Paper
DOI: 10.1039/D1CE01492G
Publication date: 10 de dezembro de 2021[:]

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