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[:pb]Green Synthesis of Five- and Six-membered N-heterocycles by Ultrasonic Irradiation in Aqueous Media [:]

[:pb]Authors: Nogueira, T. C. M.; De Souza, M. V. N.
Source: Current Green Chemistry, v. 8, p. 99-126, 2021
Publisher: Bentham Science Publishers


Abstract

Five- and six-membered N-heterocyclic compounds play an important role in medicinal chemistry and the development of new drugs. There is a constant demand for the development of novel biologically potent compounds, and there is also an increasing pressure to develop alternative and more sustainable synthetic methodologies following the Green Chemistry principles. Thus, the present review aims to compile the latest progress in the use of ultrasound irradiation in water conditions to mediate the synthesis of five- and six-membered N-heterocyclic compounds in an environmentally benign manner.


Keywords:  N-heterocycles, green chemistry, anti-cancer, ultrasound, sonochemistry, organic synthesis, MCR.
Document Type: Review Article
DOI: 10.2174/2213346108666210423120316
Publication date: 1 de Agosto de 2021[:]

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