(R*,S*)-(±)-1-(2-[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methylpiperidin-1-yl)ethanone methanol monosolvate.

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Abstract

The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C₁₉H₁₈F₆N₂O₂·CH₃OH. Each of the meth­ine­hydroxyl residue [the C-C-C-O torsion angle is -16.35 (17) °] and the piperidinyl group [distorted chair conformation] lies to one side of the quinolinyl ring system. The hydroxyl and carbonyl groups lie to either side of the mol­ecule, enabling their participation in inter­molecular inter­actions. Thus, the hydroxyl and carbonyl groups of two centrosymmetrically related mol­ecules are bridged by two methanol mol­ecules via O-HO hydrogen bonds, leading to a four-mol­ecule aggregate. These are linked into a supra­molecular chain along the a axis via C-HO inter­actions involving the hydroxyl-O atom. The chains assemble into layers that inter­digitate along the c axis being connected by C-HF inter­actions.

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Keywords: NoneDocument Type: Research ArticleDOI: http://dx.doi.org/10.1107/S1600536811038128Publication date: 1 de Janeiro de 2011