Authors: De Souza, M.V.N.; Almeida, M.V.; Teixeira, F.M.; Amarante, G.W.; Alves, C.C.S.; Cardoso, S.H.; Mattos, A.M.; Ferreira, A.P.; Teixeira, H.C.
Source: Chemical and Pharmaceutical Bulletin, v. 55, p. 223-226, 2007. Publisher: The Pharmaceutical Society of Japan
Abstract
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.Keywords: thalidomide, thalidomide analog, TNF-α, diamine, phthalimideDocument Type: Research ArticleDOI: http://doi.org/10.1248/cpb.55.223Publication date: 1 de Fevereiro de 2007
