Current leishmaniasis drug discovery

Authors: Pinheiro, A. C.; De Souza, M. V. N. Source: Rsc Medicinal Chemistry, v. 13, p. 1029-1043, 2022 Publisher: Royal Society of Chemistry Abstract Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition, poor health services and unavailability of prophylactic control measures, neglected populations are particularly affected. Current drug regimens are outdated and […]

Drug repurposing of baricitinib for the treatment of Covid-19

Autores: de Souza, M. V. N.; Facchinetti, V.; Aboud, K. C. L.; da Penha, L. B.; Gomes, C. R. B. Source: Conjecturas, v. 22, p. 1657-5830, 2022 Publisher:  Conjecturas Abstract The drug repurposing strategy is widely used by the pharmaceutical industry nowadays. This strategy is based on researching the potential of some marketed drugs to […]

Crystal structure of N-(1,3-benzothiazol-2-yl)-4-iodobenzene-1-sulfonohydrazide: the unexpected importance of l N-H—π and I—π interactions on the supramolecular arrangement

Authors: Gomes, L. R.; Früchtl, H.; Low, J. N.; MOURIK, T.; Pinheiro, A. C.; De Souza, M. V. N.; Wardell, J. L. Source: Zeitschrift für anorganische und allgemeine Chemie (ZAAC), v. e, p. 1-9, 2022 Publisher: ZAAC Abstract The 2-hydrazinyl-1,3-benzothiazole derivatives are precursors for synthesis of several compounds of technological interest, including the Bt−NH−N=CHR1 (R1=alkyl, aryl, […]

Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes

Authors: Chazin, E. ; Martins, L.; De Souza, M. V.; Gomes, C. R.; Da Silva, A. C.; Branco, M.; Sanchez, E.; Fuly, A.; Vasconcelos, T. Source: Journal of the Brazilian Chemical Society, v. 33, p. 2-12, 2022 Publisher: SciELO Abstract This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of ntheir ability to […]

[:pb]Experimental and computational evidence for stabilising parallel, offset π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interactions in acetohydrazide derivatives[:]

[:pb]Authors: Tan, S. L. ; Cardoso, L. N. F. ; De Souza, M. V. N. ; Wardell, S. M. S. V. ; Wardell, J. L. ; Tiekink, E. R. T. Source: CrystEngComm, v. 24, p. 962-974, 2022 Publisher: Royal Society of Chemistry Abstract Parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–NC(H)Ph, along […]