N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity

Authors: Pinheiro, Alessandra C.; Kaiser, Carlos R.; LourenÇo, Maria C.S.; de Souza, Marcus V.N.; Wardell, Solange M.S.V.; Wardell, James L. Lima, G.B.; Pinto, L.S.S.; Kaiser, C.R.; Wardell, J.L.; De Freitas, C.S.; Vieira, Y.R.; Martorelli, A.; Cerbino Neto, J.; Bozza, P.T.; Wardell, S.M.S.V.; De Souza, M.V.N.; Souza, T.M.L. Source: European Journal of

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Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

Authors: Nogueira, T.C.M.; Pinheiro, A.C.; De Souza, M.V.N.; Baddeley, T.C.; Wardell, J.L.; Wardell, S.M.S.V. Source:  Journal of Molecular Structure (Print), v. 1128, p. 579-589, 2017. Publisher: Elsevier Abstract The crystal structures of four 1-aryl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives, 2, are reported: [aryl = 3-ClC6H4: 2a; 2-HOC6H4:2b;2,3-(HO)2C6H3: 2c; and 3,4-(MeO)2C6H3: 2d]

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Different weak interactions in the crystals of three isomeric ( )- -methyl- –(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides

Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Kaiser, C.R.; Wardell, J.L.; De Souza, M.V.N.; Lancaster, S.T.; Harrison, W.T.A. Source: Acta Crystallographica Section E Crystallographic Communications, v. 72, p. 1677-1682, 2016. Publisher:  International Union of Crystallography Abstract The crystal structures of three isomeric (E)-N-methyl-N‘-(nitro­benzyl­idene)-2-(thio­phen-2-yl)acetohydrazides (formula C14H13N3O3S) are described, with

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Synthesis and evaluation of copper(II) complexes with isoniazid-derived hydrazones as anticancer and antitubercular agents.

Authors: Firmino, G.S.S.; De Souza, M.V.N.; Pessoa, C.O.;  Lourenço, M.C.S.; Resende, J.A.L.C.; Lessa, J.A. Source: BioMetals (Oxford), v. 29, p. 953-963, 2016. Publisher: Springer Science Abstract In this study, the N,N,O metal chelator 2-pyridinecarboxaldehydeisonicotinoyl hydrazone (HPCIH, 1) and its derivatives 2-acetylpyridine-(HAPIH 2), 2-pyridineformamide-(HPAmIH, 3) and

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Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection

Authors: Rodrigues-Junior, V.S.; Villela, A.D.; Gonçalves, R.S.B.; Abadi, B.L.; Trindade, R.V.;Gavín, A.L.; Tudó, G.; Martín, J.G.; Basso, L.A.; De Souza, M.V.N.; Campos, M.M.; Santos, D.S. Source:  International Journal of Antimicrobial Agents (Print), v. 48, p. 203-207, 2016 Publisher: International Society of Chemotherapy Infection and Cancer

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A scalable and efficient synthesis of 3-chloro-1,2-propanediol

Authors: Pinto, L.S.S.; Silva, E.T.; De Souza, M.V.N. Source: Organic Preparations and Procedures International: The New Journal for Organic Synthesis, v. 48, p.319-320, 2016 Publisher: Taylor & Francis Group Abstract None Keywords: None Document Type: Research Article DOI: Publication date: 18 de Maio de 2016

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Variations in the intermolecular interactions in (E) benzaldehyde 7-chloro-1-methyl- 4H-quinolinyl-4-ylidene-hydrazone and seven halo derivatives

Authors: Bispo, M.L.F.; Alcantara, C.C.; Wardell, S.M.S.V.; De Souza, M.V.N.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 231(4), p.219–235, 2016 Publisher: De Gruyter Abstract Eight crystal structures are reported here: substituted (E) benzaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones, 1, [substituted benzaldehyde: XYC6H4CHO: X,Y=H,H; 2-F,H; 3-F,H; 4-F,H; 3-Cl,H; 4-Cl,H; 2-Br,H

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Crystal structures of 2-[5-nitrothien-2-yl)- CH=N–NR–CO(CH2)n]thiophene compounds (R = H or Me; n = 0 or 1)

Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N. Source: Zeitschrift für Kristallographie, v. 231(3), p.167–178, 2016 Publisher: De Gruyter Abstract The crystal structures of four acylhydrazonyl derivatives of thiophene, 2-(ArCH=N–NHCO)- thiophene, (1a), 2-(ArCH=N–NMeCO)-thiophene, (2a), 2-(ArCH=N–NHCOCH2)-thiophene, (3a) and 2-(ArCH= N–NMeCOCH2)-thiophene,

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Sobre a SSCDT

Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.