Crystal structures of (E)-2-((2-((pyridin-2-yl)hydrazonyl)methyl)phenolic compounds: different sets of classical hydrogen bonds, X-H···Y (X, Y = O, N)

Authors: Correia, N.R.L.; Nogueira, T.C.M.; Pinheiro, A.C.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V. Source: Zeitschrift für Kristallographie, v. 231, p. 271-284, 2016 Publisher:  De Gruyter Abstract Structures are reported of (E)-((2-((pyridin-2-yl)hydrazonyl)methyl)arene compounds, 2-aryl-CH=N–CH)-pyridine, 8, namely (aryl=2,4-(HO)2C6H3, 8a; 2,5-(HO)2C6H3, 8b, 2–HOC6H4, 8c, as the hemihydrate, [(8c)2·

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Synthesis and anti-tubercular activity of Thienyl and Furanyl derivatives

Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 5(1), 356-366, 2016 Publisher: Astucia Group Abstract The synthesis and anti-tubercular activity of series of acyl hydrazonyl compounds, namely (E)-N’-(arylidene)thiophen-2-carbohydrazide, (E)- N’-(arylidene)furan-2-carbohydrazide, (E)-N-methyl- N’-arylidene-thiophen-2-carbohydrazide, and

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Further study of oxazolidines derived from mefloquine and arenealdehydes: diastereoisomers and polymorphs

Authors: Pinheiro, Alessandra C.; Kaiser, Carlos R.; LourenÇo, Maria C.S.; de Souza, Marcus V.N.; Wardell, Solange M.S.V.; Wardell, James L. Goncalves, R.S.B.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 231(1), p. 35–46, 2016 Publisher: De Gruyter Abstract The reaction between racemic erythro [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol] and 2-formyl-5-nitrothiene

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Synthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives

Authors: Silva, E.T.; Araújo S.A.; Moraes, A.M.; Souza, L.A.; Lourenço, M.C.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V. Source: Scientia Pharmaceutica, v. 84, p. 467-483, 2016 Publisher: Austrian Pharmaceutical Society Abstract Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C9H16C=O, into a number

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N'-[(1E)-(5-Nitro­furan-2-yl)methyl­idene]thio­phene-2-carbohydrazide: crystal structure and Hirshfeld surface analysis

Authors:  Cardoso, L.N.F.; Nogueira, T.C.M.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N.; Jotani, M.M.; Tiekink, E.R.T. Source: Acta Crystallographica Section E Crystallographic Communications, v. 72, p. 1025-1031, 2016 Publisher: International Union of Crystallography Abstract In the title carbohydrazide, C10H7N3O4S, the dihedral angle between the terminal

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Aqueous Molecular Dynamics Simulations of the M. tuberculosis Enoyl-ACP Reductase-NADH System and Its Complex with a Substrate Mimic or Diphenyl Ethers Inhibitors.

Authors: Lima, C.H.S.; De Alencastro, R.; Kaiser, C.R.; De Souza, M.V.N.; Rodrigues, C.; Albuquerque, M. Source:  International Journal of Molecular Sciences (Online), v. 16, p. 23695-23722, 2015. Publisher: Multidisciplinary Digital Publishing Institute (MDPI) Abstract Molecular dynamics (MD) simulations of 12 aqueous systems of the NADH-dependent

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A new and potent class of quinoline derivatives against cancer

Authors: Bispo, M.L.F.; Alcântara, C.C.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Kaiser, C.R.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Monatshefte fur Chemie, v. 146, p. 2041-2052, 2015 Publisher: Springer International Publishing AG   Abstract A new class of 4-quinolinylhydrazone derivatives has been synthesized

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Weak C-H…O and C-H…π hydrogen bonds and π-π stacking interactions in a series of four -N'-[(E)-(aryl)methylidene]- -methyl-2-oxo-1,3-oxazolidine-4-carbohydrazides

Authors: Nogueira, T.C.M.; Pinheiro, A.C.; Wardell, J.L.; De Souza, M.V.N.; Abberley, J.P.; Harrison, W.T.A. Source: Acta Crystallographica Section C Structural Chemistry, v. 71, p. 1-10, 2015 Publisher: International Union of Crystallography Abstract Oxazolidin-2-ones are widely used as protective groups for 1,2-amino alcohols and chiral derivatives

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Sobre a SSCDT

Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.