Substâncias Heteroaromáticas

Os heterociclos aromáticos, conhecidos também como heteroaromáticos, podem ser definidos como substâncias que possuem um ou mais átomos no anel aromático que não o átomo de carbono. Essa classe de substâncias é extremamente importante no desenvolvimento de novos medicamentos, estando presente em um grande número de fármacos. Para que o leitor tenha uma ideia da sua importância, basta dar uma rápida folheada no livro texto e no presente livro para concluir que eles estão presentes em um grande número de importantes substâncias bioativas. Abaixo estão relacionados alguns desses núcleos, valendo a pena ressaltar que, devido a sua imensa variedade estrutural, somente os mais comumente utilizados foram mencionados. Os exercícios desse item foram baseados na formação de diferentes substâncias heteroaromáticas, cabendo ao leitor a identificação dos respectivos núcleos.

Questão 1 Após a reação com a hidrazina (NH₂NH₂) qual será a molécula-alvo formada? [cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/q-1-5.jpg” lightbox=”true” animation_delay=”0″]4939|https://sscdt.org/wp-content/uploads/2016/02/q-1-5.jpg|full[/cmsms_image] [cmsms_toggles mode=”accordion” animation=”fadeInLeft” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”] A utilização da hidrazina foi responsável pela formação do núcleo indazol devido à posição da função química aldeído e do átomo de flúor. [cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-1-3.jpg” lightbox=”true” animation_delay=”0″]4940|https://sscdt.org/wp-content/uploads/2016/02/r-1-3.jpg|full[/cmsms_image] [/cmsms_toggle][/cmsms_toggles][cmsms_image align=”center” caption=”Questão 3″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-3-6.jpg” lightbox=”true” animation=”fadeInLeft” animation_delay=”0″ classes=”pergunta aligncenter”]4946|https://sscdt.org/wp-content/uploads/2016/02/q-3-6.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInLeft” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-3-3.jpg” lightbox=”true” animation_delay=”0″]4947|https://sscdt.org/wp-content/uploads/2016/02/r-3-3.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”center” caption=”Questão 5″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-5-5.jpg” lightbox=”true” animation=”fadeInLeft” animation_delay=”0″ classes=”pergunta aligncenter”]4950|https://sscdt.org/wp-content/uploads/2016/02/q-5-5.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInLeft” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-5-2.jpg” lightbox=”true” animation_delay=”0″]4951|https://sscdt.org/wp-content/uploads/2016/02/r-5-2.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”center” caption=”Questão 7″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-7-2.jpg” lightbox=”true” animation=”fadeInLeft” animation_delay=”0″ classes=”pergunta aligncenter”]4954|https://sscdt.org/wp-content/uploads/2016/02/q-7-2.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInLeft” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-7-2.jpg” lightbox=”true” animation_delay=”0″]4955|https://sscdt.org/wp-content/uploads/2016/02/r-7-2.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”center” caption=”Questão 9″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-9-1.jpg” lightbox=”true” animation=”fadeInLeft” animation_delay=”0″ classes=”pergunta aligncenter”]4958|https://sscdt.org/wp-content/uploads/2016/02/q-9-1.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInLeft” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-9-1.jpg” lightbox=”true” animation_delay=”0″]4959|https://sscdt.org/wp-content/uploads/2016/02/r-9-1.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_text animation=”fadeInRight” animation_delay=”0″] Questão 2 [cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/q-2-6.jpg” lightbox=”true” animation_delay=”0″]4941|https://sscdt.org/wp-content/uploads/2016/02/q-2-6.jpg|full[/cmsms_image] Pela análise dos materiais de partida fica fácil identificarmos a substância heteroaromática que será formada. [cmsms_toggles mode=”accordion” animation=”fadeInRight” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-2-1.jpg” lightbox=”true” animation_delay=”0″]4942|https://sscdt.org/wp-content/uploads/2016/02/r-2-1.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”none” caption=”Questão 4″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-4-6.jpg” lightbox=”true” animation=”fadeInRight” animation_delay=”0″ classes=”pergunta aligncenter”]4948|https://sscdt.org/wp-content/uploads/2016/02/q-4-6.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInRight” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-4-4.jpg” lightbox=”true” animation_delay=”0″]4949|https://sscdt.org/wp-content/uploads/2016/02/r-4-4.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”center” caption=”Questão 6″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-6-2.jpg” lightbox=”true” animation=”fadeInRight” animation_delay=”0″ classes=”pergunta aligncenter”]4952|https://sscdt.org/wp-content/uploads/2016/02/q-6-2.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInRight” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-6-1.jpg” lightbox=”true” animation_delay=”0″]4953|https://sscdt.org/wp-content/uploads/2016/02/r-6-1.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles][cmsms_image align=”none” caption=”Questão 8″ link=”https://sscdt.org/wp-content/uploads/2016/02/q-8-1.jpg” lightbox=”true” animation=”fadeInRight” animation_delay=”0″ classes=”pergunta aligncenter”]4956|https://sscdt.org/wp-content/uploads/2016/02/q-8-1.jpg|full[/cmsms_image][cmsms_toggles mode=”accordion” animation=”fadeInRight” animation_delay=”0″ classes=”resposta”][cmsms_toggle title=”Clique aqui para ver a resposta”][cmsms_image align=”center” link=”https://sscdt.org/wp-content/uploads/2016/02/r-8-1.jpg” lightbox=”true” animation_delay=”0″]4957|https://sscdt.org/wp-content/uploads/2016/02/r-8-1.jpg|full[/cmsms_image][/cmsms_toggle][/cmsms_toggles]