Ultrasound-assisted Synthesis of β-(N-arylamino)acrylates Derivatives, Key Intermediates of Biopotent Compounds
Authors: Costa, G.O.; Facchinetti, V.; Fernandes, G.O.G.; Pimentel, A.M.B.; Gomes, C.R.B.; Wardell, J.L.; Wardell, S.M.S.; De Souza, M.V.N. Source: Letters in Organic Chemistry, v. 22(1), p. 61-69, 2025 Publisher: Bentham Science Abstract β-(N-arylamino)acrylates are building blocks of great industrial interest as they allow the obtention of a variety of heterocyclic substances, such as […]
Synthetic camphor derivative (E)-2-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)phenol: A novel anthelmintic drug candidate for visceral toxocariasis
Authors: Rodrigues, D.C.; Da Cunha, C.N.O.; Faria, A.M.; Panassolo, V.P.; Martins, L.H.R.; De Souza, M.V.N.; De Souza, M.C.F.D.; Munhoz, L.S.; Da Costa De Avila, L.F.; Ramos, D.F.; Scaini, C.J. Source: Journal of Helminthology, v. 99, p. e19, 2025 Publisher: Cambridge University Press Abstract This study aimed to identify a camphor derivative with activity against Toxocara […]
Green Oxidation of Menthol in Multigram Scale Based on Calcium Hypochlorite
Authors: Carlos, M.F.L..; De Souza, M. V. N. Source: Universal Journal of Green Chemistry, v. 1, p. 96-102,, 2024 Publisher: Universal Wiser Publisher Abstract The oxidation reaction stands as a fundamental process in organic synthesis, holding significant importance ingenerating various value-added chemical products. Oxidative processes are pivotal realms for both industrial and academicexploration. Present-day […]
Synthesis, biological evaluation and mechanism of action of benzothiazole derivatives with aromatic hydrazone moiety, a new class of antileishmanial compounds
Authors: Coimbra, E.S.; Antinarelli, L.M.R.; Lemos, A.S.O.; Da Silva Neto, A.F.; Pinheiro, A.C.; De Souza, M.V.N. Source: Chemical Biology & Drug Design, v. 104(1). p. e14585, 2024 Publisher: Wiley Abstract In this work, a series of benzothiazole derivatives was synthetized and assayed against promastigotes and intracellular amastigotes of L. amazonensis, as well as the toxicity […]
Larvicidal activity of coumarin derivatives on Toxocara canis larvae, cytotoxicity analysis, and in silico bioavailability studies
Authors: Rodrigues, D.C.; Cunha, C.N.O.; Mattos, G.T.; Martins, L.H.R.; Nogueira, T.C.M.; De Souza, M.V.N.; Avila, L.F.C.; Ramos, D.F.; Scaini, C.J. Source: Parasitology Research, v. 123, p. 246, 2024 Publisher: Springer Abstract Human toxocariasis is a neglected anthropozoonosis with global distribution. Treatment is based on the administration of anthelmintics; however, their effectiveness at the tissue […]
Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents
Authors: Facchinetti, V. ; Gomes, C.R.B.; Aboud, K.; Fiorot, R.; De Carvalho, G.; Paier, C.R.; Do Ó Pessoa, C.; Gomes, A.C. ; De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Journal of the Brazilian Chemical Society, v. 35(2), p. e-20230139, 2024 Publisher: Brazilian Chemical Society Abstract This work describes the multigram-scale synthesis of the building-block N1-(7-chloroquinolin-4-yl)ethane-1,2-diamine […]
Obtenção de aminas primárias a partir da redução de nitrocompostos aromáticos via protocolos de reações sustentáveis parte ii: em meio orgânico
Authors: Pinto, L.S.S.; Fachinetti, V.; Bernardes, B.S.; Da Costa, T.M.; Da Silva, L.O.J.L.; Macedo, D.M.; Oliveira, I.P.; Vasconcelos, T.R.A.; De Souza, M.V.N. Source: Quimica Nova, v. 47(7), p. e20240017, 2024 Publisher: Sociedade Brasileira de Quimica Abstract The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and […]
4-Quinolinylhydrazone analogues kill Leishmania (Leishmania) amazonensis by inducing apoptosis and mitochondria-dependent pathway cell death
Authors: Granato, J.T.; Da Silva, E.T.; Lemos, A.S.O.; Machado, P.A.; Midlej, V.V.; Antinarelli, L.M.R.; Da Silva Neto, A.F.; De Souza, M.V.N.; Coimbra, E.S. Source: Chemical Biology & Drug Design, v. 103(5), p. e14535, 2024 Publisher: Wiley Abstract Despite efforts, available alternatives for the treatment of leishmaniasis are still scarce. In this work we tested […]
Primaquine Analysis in Pharmaceutical Formulation Using Multiple and Short-End Injections by Capillary Zone Electrophoresis-Ultraviolet Detection
Authors: De Souza, J.C.Q.; Chellini, P.R.; De Souza, M.V.N.; De Oliveira, M.A.L. Source: Journal of Separation Science, v. 47(22), p. e70026, 2024 Publisher: Wiley Abstract Novel methods were proposed for determining primaquine (PQN) in tablets by multiple-injection capillary zone electrophoresis (MI-CZE) and by short-end injection CZE (SEI-CZE), both with ultraviolet detection. The background […]
Synthesis and Anti-bacterial Activity Evaluation against of New Quinoline Derivatives Coupled with the Camphor Nucleus
Authors: Andrade, G.F.; Da Silva, E.T.; Lourenço, M.C.S.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Letters in Organic Chemistry, v. 21(2), p. 107-115,, 2023 Publisher: Bentham Science Abstract The objective of the study was to synthesize and evaluate ten new compounds containing camphor nucleus coupled to quinolinic derivatives as probable inhibitors of sensitive […]
Structural Metamorphosis: Rearranging Camphor-based Systems
Authors: Carlos, M.F.L.; Gomes, C.R.B.; Facchinetti, V.; De Souza, M.V.N. Source: Current Organic Chemistry, v. 29(12), p. 913-920, 2025 Publisher: Bentham Science Abstract Natural compounds are pivotal sources for synthesizing a vast array of biologically active substances in chemistry. Camphor is one of these substances, and both enantiomers are readily obtainable and play significant […]
Synthesis and Anti-bacterial Activity of New Substituted 2- trifluoromethyl-4-quinolinylhydrazone Analogs against Strains
Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Current Medicinal Chemistry, v. 31, p. 6713-6721, 2024 Publisher: Bentham Science Abstract The objective of this study is to synthesize and evaluate forty-four substituted 2-trifluoromethyl-4-quinolinylhydrazone analogs, as probable inhibitors of Mycobacterium tuberculosis growth. The anti-mycobacterial activities of all tested compounds against Mycobacterium […]
