Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis
Authors: Memedovski, R. ; Preza, M. ; Müller, J. ; Kämpfer, T. ; Rufener, R. ; De Souza, M.V.N.; Da Silva, E.T.; Andrade, G.F.; Braga, S.; Uldry, A.-C. ; Buchs, N. ; Heller, M. ; Lundström-Stadelmann, B. Source: International Journal for Parasitology: Drugs and Drug Resistance, v. 21, p. 114-124, 2023 Publisher: Elsevier […]
Antimicrobial Activities of Substituted 4-N-alkylated-2-trifluoromethylquinoline Analogs Against Nontuberculous Mycobacteria
Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 20(11), p. 1861-1866, 2022 Publisher: Bentham Science Abstract In this study fifty-five substituted 4-N-alkylated-2-trifluoromethylquinolines were evaluated against five species of nontuberculous mycobacteria: Mycobacterium fortuitum, Mycobacterium chelonae, Mycobacterium abscessus, Mycobacterium kansasii, and Mycobacterium avium. 47 compounds […]
Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease
Authors: Da Silva, L.L.; Leite, B.F.; Da Silva, E.T.; De Souza, M.V.N. Source: Medicine Research, v. 7, p. 230002, 2023 Publisher: Royal Society of Chemistry Abstract Alzheimer’s disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age […]
Camphor nitroimine: a key building block in unusual transformations and its applications in the synthesis of bioactive compounds
Authors: Da Silva, E.T.; Santos, L.S.; Andrade, G.F.; Rosa, E.J.R.; De Souza, M.V.N. Source: Molecular Diversity, v. 26, p. 3463-3483, 2022 Publisher: Springer Nature Abstract The development of new drugs requires a lot of time and high financial investments. It involves a research network in which there is the participation of several researchers from different […]
Experimental and computational evidence for stabilising parallel, offset π[C(-O)N(H)N-C]-π(phenyl) interactions in acetohydrazide derivatives
Authors: Tan, S.L.; Cardoso, L.N.F.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: CrystEngComm, v. 24, p. 962-974, 2022 Publisher: Royal Society of Chemistry Abstract Parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–NC(H)Ph, along with more conventional non-covalent interactions. All notable interactions were analysed using Hirshfeld surface analysis, NCI plots […]
Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes
Authors: Chazin, E.L.; Martins, L.B.; De Souza, M.V.N.; Gomes, C.R.B.; Da Silva, A.C.R.; Branco, M.C.; Sanchez, E.F.; Fuly, A.L.; Vasconcelos, T.R.A. Source: J. Braz. Chem. Soc., v. 33(1), p. 2-12, 2022 Publisher: Sociedade Brasileira de Química Abstract This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in […]
Crystal structure of N-(1,3-benzothiazol-2-yl)-4-iodobenzene-1-sulfonohydrazide: the unexpected importance of l N-H—π and I—π interactions on the supramolecular arrangement
Authors: Gomes, L.R.; Früchtl, H.; Low, J.N.; Van Mourik, T.;Pinheiro, A.C.; De Souza, M.V.N.; Wardell, J.L. Source: Zeitschrift für anorganische und allgemeine Chemie, v. 648(17), p. e202200087, 2022 Publisher: Wiley Abstract The 2-hydrazinyl-1,3-benzothiazole derivatives are precursors for synthesis of several compounds of technological interest, including the Bt−NH−N=CHR1 (R1=alkyl, aryl, heteroaryl), derivatives. Usually when Bt−NH−NH2 is […]
