Authors: Andrade, G.F.; Da Silva, E.T.; Lourenço, M.C.S.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N.
Source: Letters in Organic Chemistry, v. 21(2), p. 107-115,, 2023
Publisher: Bentham Science
Abstract
The objective of the study was to synthesize and evaluate ten new compounds containing camphor nucleus coupled to quinolinic derivatives as probable inhibitors of sensitive and resistant strains of Mtb growth. The final compounds were obtained in good yields, with derivative 3e being the most promising with high activity and low cytotoxicity. Such findings open new perspectives for drug development based on the incorporation of camphor nucleus in selected compounds.
Document Type: Research Article
DOI: 10.2174/1570178620666230818092746
Publication date: 6 de outubro de 2023
