[:pb]Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry[:]

[:pb]Authors: Costa, C.F. ; De Souza, M. V. N. ; Facchinetti, V. ; Gomes, C. R. B.
Source: General Chemistry, v. 7, p. 210004, 2021
Publisher: General Chemistry

Abstract

This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, and applicable to the synthesis of a wide variety of piperazine derivatives, being very useful in medicinal chemistry and other fields.

Keywords: piperazine, medicinal chemistry, chloridrate, alkylation and acylation, green chemistry
Document Type: Research Article
DOI: 10.21127/yaoyigc20210004
Publication date: 27 de maio de 2021[:]