Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N.
Source: Current Medicinal Chemistry, v. 31, p. 6713-6721, 2024
Publisher: Bentham Science
Abstract
The objective of this study is to synthesize and evaluate forty-four substituted
2-trifluoromethyl-4-quinolinylhydrazone analogs, as probable inhibitors of Mycobacterium tuberculosis growth. The anti-mycobacterial activities of all tested compounds against Mycobacterium tuberculosis strains, as well as the cytotoxicity test, were evaluated using the in vitro microplate procedure with broth microdilution assay. This study indicates the importance of the hydrazone function to obtain promising anti-TB compounds and open new perspectives for drug development.
Document Type: Research Article
DOI: 10.2174/0109298673267136231003113803
Publication date: 15 de outubro de 2023
