Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogs
Authors: De Souza, M.V.N.; Cunico, W.; Cechinel, C.A.; Bonacorso, H.G.; Martins, M.A.P.; Zanatta, N.; Soares, R.P.P.; Krettli, A.U. Source: Bioorganic & Medicinal Chemistry Letters, v. 16, p. 649-653, 2006. Publisher: Elsevier Abstract The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant […]
