Synthesis and antimycobacterial evaluation of N -[(E)-(monosubstituded-benzylidene)]-2-pyrazinecarbohyrazide derivatives
Authors: Vergara, F.M.F.; Lima, C.H.S.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; Ferreira, M.L.; Kaiser, C.R.; De Souza, M.V.N. Source: European Journal of Medicinal Chemistry, v. 44, p. 4954-4959, 2009. Publisher: Elsevier Abstract The present article describes a series of twenty-six N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide (4–29), which were synthesized and evaluated for their cell viabilities in non infected and […]
Promising candidates in clinical trials against multidrug-resistant tuberculosis (MDR-TB) based on natural products
Authors: De Souza, M.V.N. Source: Fitoterapia. Edizione Farmaceutica, v. 80, p. 453-460, 2009. Publisher: Elsevier Abstract In the twenty first century the interest in new anti-tuberculosis drugs based on natural products, specially against MDR (multidrug-resistant) and XDR (extensively drug resistant) tuberculosis (TB) is growing, as indicated by the increasing number of publications in this field. […]
