Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3.
Authors: Vellasco, W.T.; Guedes, G.P.; Vasconcelos, T.R.A.; Vaz, M.G.F.; De Souza, M.V.N.; Krettli, A.U.; Krettli, L.G.; Aguiar, A.C.C.; Gomes, C.R.B.; Cunico, W. Source: European Journal of Medicinal Chemistry, v. 46, p. 5688-5693, 2011. Publisher: Elsevier Abstract A series of novel thioetherhydroxyethylsulfonamide derivatives has been synthesized from the coupling of intermediates 3-amino-4-phenyl-1-thioetherazine-butan-2-oles 6,7 with arenesulfonyl chlorides […]
Synthesis, cytotoxicity, and in vitro antileishmanial activity of mono-t-butyloxycarbonyl-protected diamines.
Authors: Pinheiro, A.C.; Rocha, M.N.; Nogueira, P.M.; Nogueira, T.C.M.; Jasmim, L.F.; De Souza, M.V.N.; Soares, R.P. Source: Diagnostic Microbiology and Infectious Disease, v. 71, p. 273-278, 2011. Publisher: Elsevier Abstract Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis. This species is often associated with drug resistance, and the conventional treatments exhibit […]
