Synthesis and Antitumoral Evaluation of Benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate
Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Pinheiro, A.C.; Nogueira, T.C.M.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 9(3), p. 257-262, 2012. Publisher: Bentham Science Abstract A series of 14 N-acyl-hydrazones L-serine derivatives have been synthesized and evaluated for their in vitro antitumoral activities against four neoplastic cancer […]
Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives
Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Pinheiro, A.C.; Nogueira, T.C.M.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 9, p. 251-256, 2012. Publisher: Bentham Science Abstract A series of fourteen polysubstituted 7-chloro-4-quinolinylhydrazone derivatives (3a-n) has been synthesized and evaluated for their activity against four cancer cell lines. Among […]
Mefloquine oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113
Authors: Gonçalves, R.S.B.; Kaiser, C.R.; Lourenço, M.S.C.; Bezerra, F.A.F.M.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Henriques, M.G.M.O.; Costa, T. Source: Bioorganic & Medicinal Chemistry (Print), v. 20, p. 243-248, 2012. Publisher: Elsevier Abstract Ten new mefloquine–oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1: aryl = substituted phenyl) and 4-[(1S,8aR)-3-(heteroaryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline [2: heteroaryl = 5-nitrothien-2-yl (2a); 5-nitrofuran-2-yl (2b) and 4H-imidazol-2-yl) (2c)], have been synthesized and […]
