A new synthesis of chiral oxazolidinones from the amino acid L-serine
Authors: Nogueira, T.C.M.; Pinheiro, A.C.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N. Source: Letters in Organic Chemistry, v. 10, p. 1-2, 2013. Publisher: Bentham Science Abstract Cyclization of the (4S)-PhCH2OCONHCH(CH2OH)CONHN=CH-aryl, obtained in 4 steps from L-serine, on treatment with MeI and potassium carbonate, generates the chiral oxazolidinones, (4S)-N’-[(E)-(phenyl)methylidene]-Nmethyl- 2-oxo-1,3-oxazolidine-4-carbohydrazides. Overall the formation of […]
