Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

Authors: Carvalho, S.A.; Silva, E.F.; Lourenço, M.C.; De Souza, M.V.N.; Fraga, C.A.M.


Abstract

In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.
Keywords: 1,3,4-thiadiazoles; Antimycobacterial activity; N-arylhydrazones; TuberculosisDocument Type: Research ArticleDOI: http://dx.doi.org/10.2174/157018010792062768Publication date: 1 de Outubro de 2010

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