Authors: De Souza, M.V.N.; Almeida, M.V.; Hyaric, M.L.; Amarante, G.W.; Cardoso, S.H.
Source: Química Nova, v. 26, n.5, p. 694-698, 2003.
Publisher: Sociedade Brasileira de Química
Abstract
In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor. As a consequence it possesses neurotoxic activity resulting from overstimulation of the receptor. Quinolinic acid is implicated as an etiological factor in a range of neurodegenerative disease including AIDS related dementia, Huntington´s disease and Lyme disease. In the design of novel therapies to treat these diseases, some molecules have been identified as an important target. In this paper we described different methods to prepare quinolinic acid and derivatives.Keywords: quinolinic acid; NMDA receptor; AIDS related dementia. Document Type: Review Article DOI: http://dx.doi.org/10.1590/S0100-40422003000500013 Publication date: 1 de outubro de 2003
