Authors: Da Silva, M.M.; Silva, D.O.; Gomes, C.R.B.; De Souza, M.V.N.
Source: Revista Virtual de Química, v. 2, p. 105-117, 2010
Publisher: Sociedade Brasileira de Química
Abstract
Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. According to statistical dates each year, 9.27 million people worldwide develop active TB and almost 1.77 million die. Due to the rapid spread of multi-drug resistant TB strains and cases of co-infection TB-HIV, it is necessary the development of new drugs to fight tuberculosis. In this context, the class of nitroimidazole represents a promising strategy because of its potent activity against anaerobic bacteria. Therefore, the aim of this review is to present the importance of nitroimidazoles in modern medicinal chemistry and the promising perspectives and drugs undergoing clinical evaluation for the treatment of TB.Keywords: tuberculosis; nitroimidazoles; drugs Document Type: Research Article DOI: http://dx.doi.org/10.5935/1984-6835.20100010 Publication date: 12 de Outubro de 2010
