Authors: De Souza, M.V.N.; Almeida, M.V.
Source: Química Nova, v. 25, n.1, p. 89-98, 2002
Publisher: Sociedade Brasileira de Química
Abstract
In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products.Keywords: ortho-metalation; directed metallation group; heteroaromatic compounds. Document Type: Review Article DOI: http://dx.doi.org/10.1590/S0100-40422002000100016 Publication date: 1 de Janeiro de 2002
