Authors: Carvalho, S.A.; Silva, E.F.; De Souza, M.V.N.; Lourenço, M.C.S.; Vicente, F.R.C.
Source: Bioorganic & Medicinal Chemistry Letters, v. 18, p. 538-541, 2008.
Publisher: Elsevier
Abstract
In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a–d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.Keywords:trans-Cinnamic acid;Isoniazid; Antimycobacterial activityTuberculosis; Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.bmcl.2007.11.091 Publication date: 15 de Janeiro de 2008
