Authors: Candea, A.L.P.; Ferreira, M.L.; Pais, K.C.; Cardoso, L.N.F.; Kaiser, C.R.; Henriques, M.G.M.O.; Lourenço, M.C.S.; Bezerra, F.A.F.M.; De Souza, M.V.N.
Source: Bioorganic & Medicinal Chemistry Letters, v. 19, p. 6272-6274, 2009.
Publisher: Elsevier
Abstract
A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a–u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 μg/mL), which can be compared with that of the first line drugs, ethambutol (3.12 μg/mL) and rifampicin (2.0 μg/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds.Keywords:Tuberculosis; Drugs; Quinoline Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.bmcl.2009.09.098 Publication date: 15 de Novembro de 2009
