Authors: Ferreira, M.L.; Gonçalves, R.S.B.; Cardoso, L.N.F.; Kaiser, C.R.; Candea, A.L.P.; Henriques, M.G.M.O.; Lourenço, M.C.; Bezerra, F.A.F.M.; De Souza, M.V.N.
Source: The Scientific World Journal, v. 10, p. 1347-1355, 2010
Publisher: Hindawi Publishing Corporation
Abstract
Two series of N’(E)-heteroaromatic-isonicotinohydrazide derivatives (3a-f and 4a-b) and 1-(7-chloroquinolin-4-yl)-2-[(heteroaromatic)methylene]hydrazone derivatives (5a-f and 6a-b) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Several compounds were noncytotoxic and exhibited significant minimum inhibitory concentration (MIC) activity (3.12, 2.50, 1.25, or 0.60 μg/mL), which can be compared to that of the first-line drugs ethambutol (3.12 μg/mL) and rifampicin (2.0 μg/ml). These results can be considered an important starting point for the rational design of new leads for anti-TB compounds.Keywords: tuberculosis, quinoline, isoniazid, drugs Document Type: Research Article DOI: http://dx.doi.org/10.1100/tsw.2010.124 Publication date: 7 de Julho de 2010
