Authors: Gonçalves, R.S.B.; Kaiser, C.R.; Lourenço, M.C.S.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Da Silva, A.D.
Source: European Journal of Medicinal Chemistry, p. 6095-6100, 2010
Publisher: Elsevier
Abstract
In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.Keywords: Tuberculosis; Quinoline; Mefloquine
Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.ejmech.2010.09.024 Publication date: 1 de Dezembro de 2010
