Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates

Authors: Saraiva, M.F.; De Souza, M.V.N.; Tran Huu Dau, M.E.; Araújo, D.P.; Carvalho, G.S.G.; Almeida, M.V.


Abstract

We describe in this work the synthesis of nine new fluoroquinolone derivatives based on modifications at the C-7 position of the known fluoroquinolones cipro-, gati-, and moxifloxacin, as well as their antitubercular evaluation. The synthesis of these new analogues was improved using microwave irradiation, providing several advantages such as better yields and shorter reaction times, in comparison with classical reaction conditions. Derivatives 4, 5, and 7 exhibited promising antitubercular activities.
Keywords: Fluoroquinolones; Carbohydrate; Tuberculosis; Microwave activation
Document Type: Research ArticleDOI: http://dx.doi.org/10.1016/j.carres.2010.01.016Publication date: 19 de Abril de 2010

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