Authors: Cardoso, S.H.; Almeida, M.V.; Assis, J.V.; Diniz, R.; Speziali, N.L.; De Souza, M.V.N.
Source: Journal of Sulfur Chemistry, v. 29, p. 145-149, 2008.
Publisher: Taylor & Francis Group
Abstract
Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) is a structural analog of isoniazid that is typically used when the patient exhibits resistance to the front-line drugs, being one of the most frequently used drugs, for the treatment of drug-resistant tuberculosis. Due to the importance of ETH in TB treatment, the aim of our work was the synthesis and characterization of oxazolinyl (1,2) and N-hydroxyalkyl (3–5) ETH derivatives.Keywords: tuberculosis, ethionamide, oxazolinyl nucleus Document Type: Research Article DOI: http://dx.doi.org/10.1080/17415990701845963 Publication date: 21 de Abril de 2008
