[:pb]Authors: Pinheiro. A. C.; Maranhão, S. S.; Carvalho, G. C.; Oliveira, A. C. A.; Pessoa, C. Nogueira, T. C. M.; Da Costa, C. F.; De Souza, M. V. N.
Source: Medicine Research, v. 4, p. 200016-200016, 2020
Publisher: Medicine Research
Abstract
Fourteen arenecarbaldehyde 2-pyridinylhydrazone derivatives have been synthesized and evaluated,for their cytotoxic potential against four cancer cell lines using the MTT assay. The products were characterized by 1H NMR, 13C NMR, and HRMS, and the cytotoxicity results were expressed as the concentration that induced 50% inhibition of cell growth (IC50) in μM. The most active compound was 2-pyridinecarbaldehyde 2-pyridinylhydrazone, with an IC50 value of 0.96 μM, which displayed potent and selective activity against the human prostate cancer cell line, PC3, similar to the antineoplastic drug doxorubicin.
Keywords: cancer, hydrazone, 2-pyridinylhydrazones, PC3 cancer cell line, MTT assay
Document Type: Research Article
DOI: 10.21127/yaoyimr20200016
Publication date: 30 de setembro de 2020[:]
