Authors: De Souza, M.V.N.; Pais, K.C.; Kaiser, C.R.; Peralta, M.A.; Ferreira, M.L.; Lourenço, M.C.S.
Source: Bioorganic & Medicinal Chemistry, v. 17, p. 1474-1480, 2009.
Publisher: Elsevier
Abstract
A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 μg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.Keywords: quinoline, drugs, MDR-TB, Antitubercular activity
Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.bmc.2009.01.013 Publication date: 1 de fevereiro de 2009
