Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents
Authors: Facchinetti, V. ; Gomes, C.R.B.; Aboud, K.; Fiorot, R.; De Carvalho, G.; Paier, C.R.; Do Ó Pessoa, C.; Gomes, A.C. ; De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Journal of the Brazilian Chemical Society, v. 35(2), p. e-20230139, 2024 Publisher: Brazilian Chemical Society Abstract This work describes the multigram-scale synthesis of the building-block N1-(7-chloroquinolin-4-yl)ethane-1,2-diamine […]
Obtenção de aminas primárias a partir da redução de nitrocompostos aromáticos via protocolos de reações sustentáveis parte ii: em meio orgânico
Authors: Pinto, L.S.S.; Fachinetti, V.; Bernardes, B.S.; Da Costa, T.M.; Da Silva, L.O.J.L.; Macedo, D.M.; Oliveira, I.P.; Vasconcelos, T.R.A.; De Souza, M.V.N. Source: Quimica Nova, v. 47(7), p. e20240017, 2024 Publisher: Sociedade Brasileira de Quimica Abstract The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and […]
4-Quinolinylhydrazone analogues kill Leishmania (Leishmania) amazonensis by inducing apoptosis and mitochondria-dependent pathway cell death
Authors: Granato, J.T.; Da Silva, E.T.; Lemos, A.S.O.; Machado, P.A.; Midlej, V.V.; Antinarelli, L.M.R.; Da Silva Neto, A.F.; De Souza, M.V.N.; Coimbra, E.S. Source: Chemical Biology & Drug Design, v. 103(5), p. e14535, 2024 Publisher: Wiley Abstract Despite efforts, available alternatives for the treatment of leishmaniasis are still scarce. In this work we tested […]
Primaquine Analysis in Pharmaceutical Formulation Using Multiple and Short-End Injections by Capillary Zone Electrophoresis-Ultraviolet Detection
Authors: De Souza, J.C.Q.; Chellini, P.R.; De Souza, M.V.N.; De Oliveira, M.A.L. Source: Journal of Separation Science, v. 47(22), p. e70026, 2024 Publisher: Wiley Abstract Novel methods were proposed for determining primaquine (PQN) in tablets by multiple-injection capillary zone electrophoresis (MI-CZE) and by short-end injection CZE (SEI-CZE), both with ultraviolet detection. The background […]
Synthesis and Anti-bacterial Activity Evaluation against of New Quinoline Derivatives Coupled with the Camphor Nucleus
Authors: Andrade, G.F.; Da Silva, E.T.; Lourenço, M.C.S.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Letters in Organic Chemistry, v. 21(2), p. 107-115,, 2023 Publisher: Bentham Science Abstract The objective of the study was to synthesize and evaluate ten new compounds containing camphor nucleus coupled to quinolinic derivatives as probable inhibitors of sensitive […]
Structural Metamorphosis: Rearranging Camphor-based Systems
Authors: Carlos, M.F.L.; Gomes, C.R.B.; Facchinetti, V.; De Souza, M.V.N. Source: Current Organic Chemistry, v. 29(12), p. 913-920, 2025 Publisher: Bentham Science Abstract Natural compounds are pivotal sources for synthesizing a vast array of biologically active substances in chemistry. Camphor is one of these substances, and both enantiomers are readily obtainable and play significant […]
Synthesis and Anti-bacterial Activity of New Substituted 2- trifluoromethyl-4-quinolinylhydrazone Analogs against Strains
Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Current Medicinal Chemistry, v. 31, p. 6713-6721, 2024 Publisher: Bentham Science Abstract The objective of this study is to synthesize and evaluate forty-four substituted 2-trifluoromethyl-4-quinolinylhydrazone analogs, as probable inhibitors of Mycobacterium tuberculosis growth. The anti-mycobacterial activities of all tested compounds against Mycobacterium […]
Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis
Authors: Memedovski, R. ; Preza, M. ; Müller, J. ; Kämpfer, T. ; Rufener, R. ; De Souza, M.V.N.; Da Silva, E.T.; Andrade, G.F.; Braga, S.; Uldry, A.-C. ; Buchs, N. ; Heller, M. ; Lundström-Stadelmann, B. Source: International Journal for Parasitology: Drugs and Drug Resistance, v. 21, p. 114-124, 2023 Publisher: Elsevier […]
Antimicrobial Activities of Substituted 4-N-alkylated-2-trifluoromethylquinoline Analogs Against Nontuberculous Mycobacteria
Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 20(11), p. 1861-1866, 2022 Publisher: Bentham Science Abstract In this study fifty-five substituted 4-N-alkylated-2-trifluoromethylquinolines were evaluated against five species of nontuberculous mycobacteria: Mycobacterium fortuitum, Mycobacterium chelonae, Mycobacterium abscessus, Mycobacterium kansasii, and Mycobacterium avium. 47 compounds […]
Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease
Authors: Da Silva, L.L.; Leite, B.F.; Da Silva, E.T.; De Souza, M.V.N. Source: Medicine Research, v. 7, p. 230002, 2023 Publisher: Royal Society of Chemistry Abstract Alzheimer’s disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age […]
Camphor nitroimine: a key building block in unusual transformations and its applications in the synthesis of bioactive compounds
Authors: Da Silva, E.T.; Santos, L.S.; Andrade, G.F.; Rosa, E.J.R.; De Souza, M.V.N. Source: Molecular Diversity, v. 26, p. 3463-3483, 2022 Publisher: Springer Nature Abstract The development of new drugs requires a lot of time and high financial investments. It involves a research network in which there is the participation of several researchers from different […]
Experimental and computational evidence for stabilising parallel, offset π[C(-O)N(H)N-C]-π(phenyl) interactions in acetohydrazide derivatives
Authors: Tan, S.L.; Cardoso, L.N.F.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: CrystEngComm, v. 24, p. 962-974, 2022 Publisher: Royal Society of Chemistry Abstract Parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–NC(H)Ph, along with more conventional non-covalent interactions. All notable interactions were analysed using Hirshfeld surface analysis, NCI plots […]
