Live antibiotics use bacteria to kill bacteria
ScienceNews [:en]By Elizabeth Eaton Prescribing a predator could be the answer to multidrug resistance. Journal reference: ScienceNews[:]
How eggs got their shapes: Adaptations for flight may have driven egg-shape variety in birds
From: Harvard John A. Paulson School of Engineering and Applied Sciences The evolution of the amniotic egg — complete with membrane and shell — was key to vertebrates leaving the oceans and colonizing the land and air but how bird eggs evolved into so many different shapes and sizes has long been a mystery. Now, […]
Ozone layer recovery will be delayed by chemical leaks
By Fred Pearce Leaks of a common chemical used in paints and for manufacturing are harming the ozone layer and could delay recovery of the ozone hole until 2095. Source: New Scientist Daily news. https://www.newscientist.com/article/2138753-ozone-layer-recovery-will-be-delayed-by-chemical-leaks/ Journal reference: Nature Communications
Tipping points are real: Gradual changes in CO2 levels can induce abrupt climate changes
From: Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research During the last glacial period, within only a few decades the influence of atmospheric CO2 on the North Atlantic circulation resulted in temperature increases of up to 10 degrees Celsius in Greenland — as indicated by new climate calculations. Source: ScienceDaily
Generic form of Prozac curbs some symptoms of ‘autism’ in mice
By Melissa Healy Children diagnosed with autism spectrum disorder (ASD) are commonly treated with different forms of therapy, but a cure has yet to be found. Now, a group of researchers says an antidepressant may help, the Los Angeles Times reports. The study, reported in Science Advances, suggests that a shortage of serotonin (a neurotransmitter that acts […]
N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity
Authors: Pinheiro, Alessandra C.; Kaiser, Carlos R.; LourenÇo, Maria C.S.; de Souza, Marcus V.N.; Wardell, Solange M.S.V.; Wardell, James L. Lima, G.B.; Pinto, L.S.S.; Kaiser, C.R.; Wardell, J.L.; De Freitas, C.S.; Vieira, Y.R.; Martorelli, A.; Cerbino Neto, J.; Bozza, P.T.; Wardell, S.M.S.V.; De Souza, M.V.N.; Souza, T.M.L. Source: European Journal of Medicinal Chemistry, Volume 127, 15 February 2017, Pages 434–441 Publisher: Elsevier Abstract […]
2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine
Authors: Pinheiro, Alessandra C.; Kaiser, Carlos R.; Lourenço, Maria C.S.; de Souza, Marcus V.N.; Wardell, Solange M.S.V.; Wardell, James L. Lima, G.B.; Moraes, A.M.; Araújo, A.S.; Da Silva, E.T.; De Freitas, C.S.; Vieira, Y.R.; Marttorelli, A.; Cerbino Neto, J.; Bozza, P.T.; De Souza, M.V.N.; Souza, T.M.L. Source: European Journal of Medicinal Chemistry, Volume 127, p. 334-340, 2017. Publisher: Elsevier Abstract […]
Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
Authors: Nogueira, T.C.M.; Pinheiro, A.C.; De Souza, M.V.N.; Baddeley, T.C.; Wardell, J.L.; Wardell, S.M.S.V. Source: Journal of Molecular Structure (Print), v. 1128, p. 579-589, 2017. Publisher: Elsevier Abstract The crystal structures of four 1-aryl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives, 2, are reported: [aryl = 3-ClC6H4: 2a; 2-HOC6H4:2b;2,3-(HO)2C6H3: 2c; and 3,4-(MeO)2C6H3: 2d] The compounds, 2, were prepared by oxidation of substituted arenealdehyde […]
Different weak interactions in the crystals of three isomeric ( )- -methyl- –(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides
Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Kaiser, C.R.; Wardell, J.L.; De Souza, M.V.N.; Lancaster, S.T.; Harrison, W.T.A. Source: Acta Crystallographica Section E Crystallographic Communications, v. 72, p. 1677-1682, 2016. Publisher: International Union of Crystallography Abstract The crystal structures of three isomeric (E)-N-methyl-N‘-(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides (formula C14H13N3O3S) are described, with the nitro group in ortho, meta and para positions in […]
Synthesis and evaluation of copper(II) complexes with isoniazid-derived hydrazones as anticancer and antitubercular agents.
Authors: Firmino, G.S.S.; De Souza, M.V.N.; Pessoa, C.O.; Lourenço, M.C.S.; Resende, J.A.L.C.; Lessa, J.A. Source: BioMetals (Oxford), v. 29, p. 953-963, 2016. Publisher: Springer Science Abstract In this study, the N,N,O metal chelator 2-pyridinecarboxaldehydeisonicotinoyl hydrazone (HPCIH, 1) and its derivatives 2-acetylpyridine-(HAPIH 2), 2-pyridineformamide-(HPAmIH, 3) and pyrazineformamide-(HPzAmIH, 4) were employed in the synthesis of four copper(II) […]
Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection
Authors: Rodrigues-Junior, V.S.; Villela, A.D.; Gonçalves, R.S.B.; Abadi, B.L.; Trindade, R.V.;Gavín, A.L.; Tudó, G.; Martín, J.G.; Basso, L.A.; De Souza, M.V.N.; Campos, M.M.; Santos, D.S. Source: International Journal of Antimicrobial Agents (Print), v. 48, p. 203-207, 2016 Publisher: International Society of Chemotherapy Infection and Cancer Abstract Repurposing of drugs to treat tuberculosis (TB) has been […]
Eco – friendly and highly efficient multigram synthesis of 3 – chloro – 1,2 – propanediol using sonochemistry
Authors: Pinto, L.S.S.; Silva, E.T.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 5, p. 624-626, 2016. Publisher: Astucia Group Abstract A new short, simple, green and an inexpensive industrially practical process for the preparation of 3-chloro-1,2-propanediol was developed by using ultrasound irradiation avoiding the use of solvents, of acidic or basic conditions. The only […]
