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Oxazolidinonas: uma nova classe de compostos no combate à tuberculose

Authors: Kaiser, C.R.; Cunico, W.; Pinheiro, A.C.; Oliveira, A.G.; De Souza, M.V.N. Source: Revista Brasileira de Farmacia, v. 88, p. 83-88, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente,a tuberculose (TB) é um grave problema de saúde pública mundial. Essa doença contagiosa é causada pela bactéria Mycobacterium tuberculosis, que ataca principalmente os pulmõıes sendo responsável a […]

Halogen Dance Reaction and its Application in Organic Synthesis.

Authors: De Souza, M.V.N. Source: Current Organic Chemistry, v. 11, p. 637-646, 2007. Publisher: Bentham Science Abstract Halogen dance (HD) reaction is an important tool in modern organic chemistry. This reaction is defined as halogen migration induced by bases, normally in aromatic and heteroaromatic systems. It is successfully applied in aromatic and different classes of […]

Problemas relacionados ao tratamento da tuberculose em pacientes com problemas hepáticos e renais

Authors: Ferreira, M.L.; Nogueira, T.C.M.; De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 88, p. 125-131, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente, a tuberculose (TB) se tornou um problema de saúde pública mundial, afetando todas as idades. Essa doença infectocontagiosa, transmitida pelo ar, cujo agente etiológico é o Mycobacterium tuberculosis é responsável por […]

Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Authors: Almeida, M.V.; De Souza, M.V.N.; Barbosa, N.;  Amarante, G.W.; Cardoso, S.H. Source: Letters in Drug Design & Discovery, v. 4, p. 149-153, 2007 Publisher: Bentham Science Abstract A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds […]

Three isomeric 1-(2-chloronicotinoyl)-2-(nitrophenyl)hydrazines, including three polymorphs of 1-(2-chloronicotinoyl)-2-(2-nitrophenyl)hydrazine:hydrogen-bonded supramolecular structures intwo and three dimensions

Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B63, p. 101-110, 2007. Publisher: International Union of Crystallography Abstract 1-(2-Chloronicotinoyl)-2-(2-nitrophenyl)hydrazine, C12H9Cl­N4O3, crystallizes in three polymorphic forms, two monoclinic forms in space groups Cc (Ia) and P21 (Ib), and an orthorhombic form in space group […]

N-(5-Chloro-2-nitrobenzoyl)-N´isonicotinoylhydrazine: a three-dimensional framework containing four types of hydrogen bond

Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section E, v. E63, p. 230-232, 2007. Publisher: International Union of Crystallography Abstract The title compound, C13H9ClN4O4, crystallizes with Z‘ = 2, and the two mol­ecules have markedly different conformations. The mol­ecules are linked into a three-dimensional framework by a […]

2,3-Dimethoxybenzaldehyde isonicotinoylhydrazone chloroform monosolvate, and the mono- and dihydrates of 3,4,5-trimethoxybenzaldehyde isonicotinoylhydrazone: hydrogen-bonded supramolecular strucutures in one, two and three dimensions

Authors: Peralta, M.A.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C63, p. 68-72, 2007. Publisher: International Union of Crystallography Abstract In 2,3-dimethoxy­benzaldehyde isonicotinoyl­hydrazone chloro­form monosolvate, C15H15N3O3·CHCl3, the hydrazone mol­ecules are linked by a combination of N-HN and C-HN hydrogen bonds into chains […]

3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K

Authors: Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C.; De Souza, M.V.N. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C63, p. 42-44, 2007. Publisher: International Union of Crystallography Abstract In the title compound, C13H10N4O3·H2O, the mol­ecular components are linked into complex sheets by a combination of four types of hydrogen bonds. Keywords: None […]

Supramolecular structures in N-isonicotinoyl arylaldehydehydrazones: multiple hydrogen-bonding modes in series of geometric isomers

Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B63, p. 879-895, 2007. Publisher: International Union of Crystallography Abstract Sixteen N-isonicotinoyl arylaldehydehydrazones, NC5H4CONHN=CHC6H4R, have been studied and the structures of 14 of them have been determined, including the unsubstituted parent compound with R = H, […]

Produtos Naturais em Fase Avançada de Testes Clínicos no Tratamento contra o Câncer

Authors: De Souza, M.V.N.; Pinheiro, A.C.; Ferreira, M.L.; Gonçalves, R.S.B.; Lima, C.H.S. Source: Revista Fitos (ALANAC), v. 3, p. 25-42, 2007. Publisher: FIOCRUZ Abstract Atualmente, os produtos naturais representam uma inestimável fonte de substâncias químicas tendo um importante papel no tratamento do câncer. Devido à importância da natureza como fonte de novos candidatos a fármacos no […]

Tuberculose Infantil: Tratamento e problemas relacionados

Authors: Ferreira, M.L.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Rocha, L.C.; De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 88, p. 38-44, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Em nossos dias, Tuberculose (TB) se tornou novamente um grave problema de saúde pública mundial, tendo sido ainda declarado pela Organização Mundial de Súde (OMS), um problema […]

Evaluation of anti-tubercular activity of nicotinic and isoniazid analogues

Authors: Lourenço, M.C.S.; De Souza, M.V.N.; Pinheiro, A.C.; Ferreira, M.L.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Peralta, M.A. Source: ARKIVOC, v. XV, p. 181-191, 2007. Publisher: Arkat USA, Inc. Abstract Several nicotinic and isoniazid derivatives, most of them containing nitro groups were synthesized by our group, and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis […]