3-[(E)-(7-Chloro-4-quinolyl)hydrazonomethyl]benzonitrile monohydrate
Authors: Ferreira, M.L.; De Souza, M.V.N.; Howie, R.A.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 65, p. 3239-3240, 2009. Publisher: International Union of Crystallography Abstract The title monohydrate, C17H11ClN4·H2O, features an essentially planar organic molecule, as seen in the dihedral angle of 2.42 (8)° formed between the quinoline and benzene planes. […]
4-[(2-Chloroethyl)amino]quinolinium chloride monohydrate
Authors: Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Acta Crystallographica. Section E, v. 65, p. 3120-3121, 2009. Publisher: International Union of Crystallography Abstract In the title salt hydrate, C11H12ClN2+·Cl–·H2O, the quinolinium core is essentially planar (r.m.s. deviation = 0.027 Å) with the chloroethyl side chain being almost orthogonal to the core [C-N-C-C torsion […]
7-Chloro-4-[(E)-(3-chlorobenzylidene)hydrazinyl]-1[lambda]4-quinolinium 3-chlorobenzoate
Authors: Howie, R.A.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Acta Crystallographica. Section E, v. 65, p. 3204-3205, 2009 Publisher: International Union of Crystallography Abstract Reactions between either L-serine methyl ester hydrochloride (1), or the cbz derivative, methyl (S)-(+)-2-(benzyloxycarbonylamino)-3-hydroxypropanoate (2), and pyrazinoyl chloride (3), have been studied. Methyl (S)-(+)-2-benzyloxycarbonylamino-3-[(pyrazinecarbonyl)oxy]propionate (4), methyl (S)-(+)-3-hydroxy-2-[(pyrazine-2-carbonyl)amino]propionoate (7), […]
N-(2,6-Dimethylphenyl)-2-(2-thienyl)acetamide
Authors: Ferreira, M.L.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L.; De Souza, M.V.N. Source: Acta Crystallographica. Section E, v. 65, p. 3203-3203, 2009. Publisher: International Union of Crystallography Abstract The thienyl ring in the title compound, C14H15NOS, is disordered over two diagonally opposite positions, the major component having a site-occupancy factor of 0.569 (3). The molecule is […]
Produtos Naturais Inibidores da Transcriptase Reversa do Vírus HIV
Authors: Gonçalves, R.S.B.; Barreto, M.B.; Gomes, C.R.B.; De Souza, M.V.N. Source: Revista Fitos (ALANAC), v. 4, p. 87-107, 2009. Publisher: FIOCRUZ Abstract Atualmente, os fármacos disponíveis no combate ao vírus da AIDS podem ser classificados em seis categorias: (a) inibidores da transcriptase reversa análogos de nucleosídeos (ITRNs), (b) inibidores da transcriptase reversa não nucleosídeos (ITRNNs), […]
Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
Authors: Cardoso, S.H.; Assis, J.V.; Almeida, M.V.; Lourenço, M.C.S.; Vicente, F.R.C.; De Souza, M.V.N. Source: Química Nova (Impresso), v. 32, p. 1557-1560, 2009 Publisher: Sociedade Brasileira de Química Abstract A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using […]
A natureza no combate à tuberculose
Authors: De Souza, M.V.N.; Cardoso, S.H.; Riente, R.R. Source: Revista Brasileira de Farmácia, v. 90, p. 95-100, 2009. Publisher: Associação Brasileira de Farmacêuticos (ABF) Abstract Atualmente, a tuberculose (TB) tornou-se novamente um sério problema de saúde pública mundial,sendo responsável pela morte de 1,7 milhões de pessoas a cada ano. O ressurgimento da TB pode ser […]
A tuberculose e o desenvolvimento de novos tuberculostáticos em Far‐Manguinhos (FIOCRUZ) no Rio de Janeiro
Authors: De Souza, M.V.N. Source: Revista Virtual de Química, v. 1, p. 9-16, 2009. Publisher: Sociedade Brasileira de Química Abstract O presente artigo tem como objetivo apresentar a importância atual da tuberculose no cenário da Saúde Pública Mundial, bem como alguns trabalhos desenvolvidos na busca de novos tuberculostáticos em Far-Manguinhos (FIOCRUZ) no Rio de Janeiro. […]
Utilização do D-manitol em síntese orgânica
Authors: De Souza, M.V.N.; Mello, S.C.P.; Ferreira, V.F. Source: Química Nova (Impresso), v. 32, p. 441-452, 2009. Publisher: Sociedade Brasileria de Química Abstract D-mannitol is used in several fields including food, pharmaceuticals, cosmetics and textiles being an important carbohydrate found widespread in nature. Due to its chirality, it is largely used in organic synthesis with […]
