Authors: Cardoso, S.H.; Assis, J.V.; Almeida, M.V.; Lourenço, M.C.S.; Vicente, F.R.C.; De Souza, M.V.N.
Source: Química Nova (Impresso), v. 32, p. 1557-1560, 2009
Publisher: Sociedade Brasileira de Química
Abstract
A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.Keywords: isoniazid analogs; carbohydrate; antimycobacterial activity. Document Type: Research Article DOI: http://dx.doi.org/10.1590/S0100-40422009000600038 Publication date: 1 de Janeiro de 2009
