7-Chloro-4-[( E )-2-(2-methoxybenzylidene)hydrazin-1-yl]quinoline monohydrate
Authors: De Souza, M.V.N.; Howie, R.A.; Tiekink, E.R.T.; Wardell, J.L.; Wardell, S.M.S.V.; Kaiser, C.R. Source: Acta Crystallographica. Section E, v. 66, p. 698-699, 2010 Publisher: International Union of Crystallography Abstract In the title hydrate, C17H14ClN3O·H2O, the dihedral angle between the quinoline fused-ring system and the benzene ring is 13.4 (2)° and the conformation about the C=N […]
2-Bromopyridine-3-carboxylic acid
Authors: Howie, R. A.; Gonçalves, R.S.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 66, p. 486-486, 2010. Publisher: International Union of Crystallography Abstract The carboxylic acid residue in the title compound, C6H4BrNO2, is twisted out of the plane of the other atoms, as indicated by the (Br)C-C-C-Ocarbonyl torsion angle […]
(2 E )- N -Benzoyl-3-(4-nitrophenyl)prop-2-enohydrazide
Authors: Carvalho, S.A.; Silva, E.F.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, J.L.; Wardell, S.M.S.V. Source: Acta Crystallographica. Section E, v. 66, p. 150-151, 2010. Publisher: International Union of Crystallography Abstract In the title compound, C16H13N3O4, the dihedral angle between the terminal benzene rings is 14.02 (7)°. The carbonyl groups are anti with respect to each other, which […]
7-Chloro-4-[( E )- N -(4-fluorobenzylidene)hydrazinyl]quinoline monohydrate
Authors: De Souza, M.V.N.; Howie, R.A.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 152-153, 2010. Publisher: International Union of Crystallography Abstract The molecule of the title hydrate, C16H11ClFN3·H2O, is slightly twisted, as indicated by the dihedral angle of 9.55 (10)° formed between the quinoline ring system and the benzene ring. […]
N-(4-Bromophenyl)-2-(2-thienyl)acetamide
Authors: Nogueira, T.C.M.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 177-177, 2010. Publisher: International Union of Crystallography Abstract The thienyl ring in the title compound, C12H10BrNOS, is disordered over two diagonally opposite positions, the major component having a site-occupancy factor of 0.660 (5). The molecule is […]
N-[(E)-2,6-Dichlorobenzylidene]pyrazine-2-carbohydrazide.
Authors: Howie, R. A.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L. ; Tiekink, E.R.T.; De Souza, M.V.N. Source: Acta Crystallographica. Section E, v. 66, p. 178-179, 2010. Publisher: International Union of Crystallography Abstract The title compound, C12H8Cl2N4O, is non-planar, the dihedral angle formed between the pendant pyrazine and benzene rings being 12.55 (11)°. An intramolecular N-HN hydrogen […]
Recent Developments in Pleuromutilin Derivatives: A Promising Class Against Bacterial Respiratory Disease
Authors: Gonçalves, R.S.B.; De Souza, M.V.N. Source: Current Respiratory Medicine Reviews, v. 6, p. 91-101, 2010. Publisher: Bentham Science Abstract In the last three decades, an increasing number of pathogens resistant to common antibiotics have been a serious threat to public health worldwide. Pleuromutilin, its derivatives and others natural products are important in the fight […]
Evaluation of Substituted Benzaldehydes Against Mycobacterium tuberculosis
Authors: Ferreira, M.L.; Candea, A.L.P.; Henriques, M.G.M.O.; Lourenço, M.C.S.; Kaiser, C.R.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 7, p. 754-758, 2010. Publisher: Bentham Science Abstract A series of 48 commercial benzaldehydes have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, using the Alamar Blue susceptibility test […]
Benzyl N-[(S)-2-hydroxy-1-({[(E)-2-hydroxy-4-methoxybenzylidene]hydrazinyl}carbonyl)ethyl]carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 66, p. 3253-3254, 2010. Publisher: International Union of Crystallography Abstract The shape of the title compound, C19H21N3O6, is curved with the conformation about the imine bond [1.291 (3) Å] being E. While the hydroxy-substituted benzene ring is almost coplanar with […]
N-(2-Chloroethyl)pyrazine-2-carboxamide
Authors: Lima, C.H.S.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 2886-2887, 2010. Publisher: International Union of Crystallography Abstract In the title molecule, C7H8ClN3O, the pyrazine and amide groups are almost co-planar [N-C-C-N torsion angle = -2.4 (2) °], a conformation stabilized by an intramolecular N-HN hydrogen […]
N-(4-Bromophenyl)pyrazine-2-carboxamide
Authors: Ferreira, M.L.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 2722-2723, 2010. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C11H8BrN3O, is close to planar (r.m.s. deviation of all 16 non-H atoms = 0.103 Å), a conformation stabilized by an intramolecular N-HN […]
Benzyl N-{(1S)-2-hydroxy-1-[N'-(2-nitrobenzylidene)hydrazinylcarbonyl]ethyl}carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 66, p. 2023-2024, 2010. Publisher: International Union of Crystallography Abstract The carbamate and hydrazone groups in the title compound, C18H18N4O6, are approximately orthogonal [dihedral angle = 83.3 (4)°], and the carbonyl groups are effectively anti [O=CC=O torsion angle = […]
