Synthesis and Antitubercular Evaluation of New Bis-1,2,3-Triazoles Derived from D-Mannitol
Authors: Ferreira, M.L.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Vasconcelos, T.R.A.; Ferreira, V.; Lourenço, M. Source: Journal of Carbohydrate Chemistry, v. 29, p. 265-274, 2010 Publisher: Taylor & Francis Group Abstract Five new bis-1,2,3-triazole derivatives from D-mannitol, namely 2,3,4,5-tetra-O-acetyl-1,6-dideoxy-1,6-bis-(4-substituted-1H-1,2,3-triazol-1-yl)-D-mannitol (4), have been synthesized from 2,3,4,5-tetra-O-acetyl-1,6-diazido-1,6-dideoxy-D-mannitol (3) and alkynes, employing copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) methodology. […]
