2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1 -1,3-oxazolo[3,4- ]pyridin-3-yl}phenol
Authors: Gonçalves, R.S.B.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 1656-1657, 2011. Publisher: International Union of Crystallography Abstract In the title mefloquine-oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair […]
Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Authors: De Souza, M.V.N.; Gonçalves, R.S.B.; .; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. o3313-o3314, 2011. Publisher: International Union of Crystallography Abstract The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline […]
tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Authors: Gonçalves, R.S.B.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 3315-3316, 2011. Publisher: International Union of Crystallography Abstract The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes […]
Synthesis and Antimycobacterial Evaluation of N'-(E)-heteroaromaticpyrazine-2-carbohydrazide Derivatives
Authors: Lima, C.H.S.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; Bezerra, F.A.F.M.; Kaiser, C.R.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 245-249, 2011 Publisher: Bentham Science Abstract A series of nine N’-(E)-heteroaromatic-pyrazine-2-carbohydrazide derivatives (5a-f and 6a-c) have been synthesized and evaluated against M. tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA), […]
2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 3-amino-5-nitrobenzoate sesquihydrate
Authors: De Souza, M.V.N.; .; Wardell, J.L.; Wardell, S.M.S.V.; Ng, S.W.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 3019-3020, 2011. Publisher: International Union of Crystallography Abstract The asymmetric unit of the title salt solvate, C17H17F6N2O+·C7H5N2O4–·1.5H2O, comprises a piperidin-1-ium cation, a 3-amino-5-nitrobenzoate anion, and three fractionally occupied [i.e. 0.414 (3), 0.627 (6) and 0.459 (5)] disordered […]
Sodium Chlorite (NaClO2): an Important Reagent in Alcohol and Aldehyde Oxidation and its Application in Total Synthesis of Natural Products
Authors: De Souza, M.V.N.; Ferreira, M.L.; Cardoso, L.N.F. Source: Journal of Biologically Active Products from Nature, v. 1, p. 52-80, 2011. Publisher: Taylor & Francis Group Abstract The oxidation of alcohols is a fundamental transformation in organic synthesis and a large number of reagents have been developed for this purpose. In spite of the different […]
