2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1 -1,3-oxazolo[3,4- ]pyridin-3-yl}phenol

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Abstract

In the title mefloquine-oxazolidine derivative, C₂₄H₂₀F₆N₂O₂, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C₆ ring of the quinoline group and, to a first approximation, to one side of the plane through the ten atoms (r.m.s. deviation = 0.025 Å). An intra­molecular O-HN(piperidine) hydrogen bond is present. The crystal packing features C-HO, C-HF and C-H(hy­droxy­benzene) inter­actions.

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Keywords: NoneDocument Type: Research ArticleDOI: http://dx.doi.org/10.1107/S1600536811022379Publication date: 1 de Janeiro de 2011