1,3-Dicyclohexyl-3-[(pyridin-2-yl)carbonyl]urea monohydrate from synchrotron radiation
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 2676-2677, 2011. Publisher: International Union of Crystallography Abstract The title urea derivative crystallizes as a monohydrate, C19H27N3O2·H2O. The central C3N grouping is almost planar (r.m.s. deviation = 0.0092 Å), and the amide and pyridine groups are substantially […]
Pirazinamida: Um Fármaco Essencial no Tratamento da Tuberculose
Authors: Lima, C.H.S.; Ferreira, M.L.; De Souza, M.V.N. Source: Revista Virtual de Química, v. 3, p. 159-180, 2011. Publisher: Sociedade Brasileira de Química Abstract A pirazinamida (PZA) é um importante fármaco utilizado contra a tuberculose, que contribuiu para a redução do tempo de tratamento de 12 para 6 meses. A principal ação desse fármaco é a […]
Benzyl N-(1-{N'-[(E)-2,3-dihydroxybenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate dihydrate
Authors: Wardell, S.M.. S.V.; Tiekink, E.R.T.; De Souza, M.V.N.; Pinheiro, A.C.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 2155-2156, 2011. Publisher: International Union of Crystallography Abstract The organic molecule in the title dihydrate, C18H19N3O6·2H2O, adopts a twisted U-shape with the major twists evident about the chiral C atom [the C-N-C-C torsion angle is […]
tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(E)-2-hydroxy-4-methoxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Wardell, J.L.; De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V. Source: Acta Crystallographica. Section E, v. E67, p. 1888-1889, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C16H23N3O6, is twisted about the chiral C atom with the dihedral angle formed between the amide residues being 76.9 (3)°. Overall, the […]
tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(1E)-4-methoxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1805-1806, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C16H23N3O5, is twisted about the chiral C atom, the dihedral angle formed between the amide residues being 79.6 (3)°. The conformation about the […]
Benzyl N-(1-{ N’-[(E)-2-chlorobenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1868-1869, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C18H18ClN3O4, is twisted about the chiral C atom with the dihedral angle between the two amide residues being 87.8 (5)°, but, overall, […]
Benzyl N-(2-hydroxy-1-{ N’-[(1E)-2-hydroxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Tiekink, E.R.T.; De Souza, M.V.N.; Pinheiro, A.C.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1866-1867, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C18H19N3O5, adopts a curved arrangement with the terminal benzene rings lying to the same side. The hydroxylbenzene ring is close to […]
N’-[(E)-2-Methoxybenzylidene]pyrazine-2-carbohydrazide
Authors: De Souza, M.V.N.; Lima, C.H.S.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 1714-1715, 2011. Publisher: International Union of Crystallography Abstract In the title compound, C13H12N4O2, all the non-H atoms lie on a crystallographic mirror plane and an intramolecular N-HN hydrogen bond generates an S(5) ring; the conformation […]
Amodiaquine analogs. Synthesis and anti-leishmanial activity
Authors: Coimbra, E.S.; Silva, A.D.; Dias, R.M.P.; Corrales, R.C.N.R.; Bispo, M.L.F.; Kaiser, C.R.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 3, p. 106-113, 2011. Publisher: Astucia Group Abstract In this work, we report the synthesis and antileishmanial evaluation of 13 amodiaquine (AQ) derivatives (4-aminoquinoline-aryl and 4-quinolinylhydrazones series). The compounds were tested against four […]
Synthesis and Antitumoral Evaluation of 7-chloro-4-quinolinylhydrazones Derivatives.
Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Bispo, M.L.F.; Cardoso, L.N.F.; Kaiser, C.R.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 599-604, 2011. Publisher: Bentham Science Abstract A series of twenty-one 7-chloro-4-quinolinylhydrazones derivatives (3a-u) have been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using […]
Synthesis and Antitubercular Activity of New L-serinyl Hydrazone Derivatives.
Authors: Pinheiro, A.C.; Kaiser, C.R.; Nogueira, T.C.M.; Carvalho, S.A.; Da Silva, E.F.; Feitosa, L.O.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 611-623, 2011. Publisher: Bentham Science Abstract A series of 32 L-serinyl hydrazone derivatives have been synthesized and evaluated for their in vitro antibacterial activity against […]
(R*,S*)-(±)-1-(2-[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methylpiperidin-1-yl)ethanone methanol monosolvate.
Authors: Gonçalves, R.S.B.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 2714-2715, 2011. Publisher: International Union of Crystallography Abstract The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C-C-C-O torsion angle is -16.35 (17) °] and the […]
