Synthesis and anti-tubercular activity of Thienyl and Furanyl derivatives
Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 5(1), 356-366, 2016 Publisher: Astucia Group Abstract The synthesis and anti-tubercular activity of series of acyl hydrazonyl compounds, namely (E)-N’-(arylidene)thiophen-2-carbohydrazide, (E)- N’-(arylidene)furan-2-carbohydrazide, (E)-N-methyl- N’-arylidene-thiophen-2-carbohydrazide, and E)-N-methyl- N’-arylidene-2-(thien-2yl)-acetohydrazide, [32 compounds in all] are reported. The activities […]
Further study of oxazolidines derived from mefloquine and arenealdehydes: diastereoisomers and polymorphs
Authors: Pinheiro, Alessandra C.; Kaiser, Carlos R.; LourenÇo, Maria C.S.; de Souza, Marcus V.N.; Wardell, Solange M.S.V.; Wardell, James L. Goncalves, R.S.B.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 231(1), p. 35–46, 2016 Publisher: De Gruyter Abstract The reaction between racemic erythro [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol] and 2-formyl-5-nitrothiene in toluene generates a reaction mixture containing two diastereoisomers of […]
Cytotoxicity and Leishmanicidal Activity of Isoniazid-Derived Hydrazones and 2-Pyrazineformamide Thiosemicarbazones
Authors: Amim, R.S.; Firmino, G.S.S.; Rego, A.C.P.D.; Nery, A.L.; Da Silva, S.A.G.; De Souza, M.V.N.; Pessoa, C.; Resende, J.A.L.C.; Figueroa-Villar, J.D.; Lessa, J.A. Source: J. Braz. Chem. Soc., v. 27(4), p.769-777, 2016 Publisher: Sociedade Brasileira de Química Abstract The isoniazid-derived hydrazones 2-pyridinecarbaldehyde- (HPCIH), 2-acetylpyridine- (HAPIH), 2-benzoylpyridine- (HBPIH), 2-pyridineformamide- (HPAmIH) and 2-pyrazineformamide- (HPzAmIH) isonicotinoyl hydrazones, […]
