Tool to navigate chemical space aims to be ‘Google Maps of drugs
The new online tool ChemMaps could help students and medicinal chemists explore chemical space in the search for new drugs. The site, which the developers dub ‘the Google Maps of drugs’, allows users to navigate a chemical universe of over 8000 drugs and 47,000 environmental problematic compounds in 3D. It enables users to search for a chemical […]
Enzyme helps photoredox get enantioselective
Enantioenriched amine synthesis is inaugural example of photoredox and enzyme collaboration Source: Royal Society of Chemistry Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network Researchers in Switzerland have successfully introduced cyclic enzymatic chemistry into a photochemical reaction to perform an enantioselective imine-to-amine reduction. The concept could act as […]
First new form of isomerism discovered in 50 years will be the last
By Katrina Krämer Source: © Macmillan Publishers Ltd The first recognised example of akamptisomerism – the molecule is shown inverting between the amplo and parvo diastereomers as it is heated. Central to this new form of isomerism is the boron–oxygen–boron bridge (pink–red–pink) held in the rigid porphyrin ring. Rings co-planar to a chelated parvo boron atom are […]
Magnetism puts new spin on separating mirror image molecules
Magnetism and electron spin have been harnessed to create a new way to separate and identify enantiomers – molecules that have a mirror image or chiral counterpart, akin to left and right hands. The approach could offer a broad, cheap and simple way to isolate certain chiral molecules, something that can be crucial to create […]
Challenging mirror molecules made with stereochemistry destroying reaction
Clever catalyst repurposes classic nucleophilic substitution to make chiral quaternary carbon centres A substitution reaction known for destroying stereochemistry has been converted into a chirality-creating reaction to tackle one of the toughest organic chemistry challenges: making quaternary carbon centres. Source: © 2018 Macmillan Publishers Ltd covalent bonds such as charge interactions and aromatic stacking allow […]
How do you make non-alcoholic beer and wine?
For Dry January and beyond, drinkers are thirsty for beers and wines that don’t get you drunk Many people will have met the New Year with a resolution to lay off the booze for a while, perhaps having overindulged in previous weeks. And with research published in early January revealing how alcohol causes DNA damage,1 […]
