Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Bispo, M.L.F.; Alcântara, C.C.; Kaiser, C.R.; De Souza, M.V.N.
AbstractHeteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.
Keywords: Antitumor activity Cancer Chloroquine Drugs Hydrazones QuinolineDocument Type: Research ArticleDOI: http://dx.doi.org/10.1007/s00044-011-9894-8Publication date: 1 de Janeiro de 2012