The Vital Importance of Sulfur for Life on Earth
Authors: De Souza, M.V.N.; Gomes, C.R.B.; Bispo, M.L.F. Source: Revista Química no Brasil, v. 6, p. 135-147, 2012. Publisher: WMF Martins Fontes Ltda. Abstract Keywords: Document Type: Review Article DOI: Publication date: 1 de Janeiro de 2012
Perspectives on the Development of Novel Potentially Active Quinolones Against Tuberculosis and Cancer
Authors: Facchinetti, V.; Gomes, C.R.B.; De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Mini-Reviews in Medical Chemistry, v. 12, p. 866-874, 2012. Publisher: Bentham Science Abstract Quinolones and its derivatives comprise an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, antiviral, anti-ischemic, antiparasitic and anxiolytic. Persistent efforts have been […]
1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer
Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Bispo, M.L.F.; Alcântara, C.C.; Kaiser, C.R.; De Souza, M.V.N. Source: Medicinal Chemistry Research (Print), v. 21, p. 3615-3619, 2012 Publisher: Springer Abstract Heteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) […]
4-[(E)-2-(2-Chlorobenzylidene)hydrazin-1-yl]quinolin-1-ium chloride dihydrate
Authors: Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L.; Ferreira, M.L.; De Souza, M.V.N.; Kaiser, C.R. Source: Acta Crystallographica. Section E, v. 68, p. 1850-1851, 2012. Publisher: International Union of Crystallography Abstract In the title hydrated salt, C16H13ClN3+·Cl–·2H2O, a small twist is evident in the cation so that the chlorobenzene ring is not coplanar with the central hydrazinyl […]
Synthesis and in vivo antimalarial evaluation of novel hydroxyethylamine derivatives
Authors: Souza, M.C.A.; Silva, T.G.; Da Silva, M.M.; Gomes, C.R.B.; Kaiser, C.R.; Henriques, M.G.M.O.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 8, p. 266-272, 2012. Publisher: Bentham Science Abstract A series of hydroxyethylamines has been synthesized from the reaction of (2S,3S)Boc-phenylalanine epoxide with alkyl amines in good yields and evaluated for their in vivo antimalarial […]
7-Chloro-4-[(E)-2-(2,5-dimethoxybenzylidene)hydrazin-1-yl]quinoline
Authors: De Souza, M.V.N.; Ferreira, M.L.; Wardell, S.M.S.V.; Tiekink, E.R.T.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 68, p. 1244-1245, 2012. Publisher: International Union of Crystallography Abstract In the nearly planar title compound (r.m.s. deviation for the 24 non-H atoms = 0.064 Å), C18H16ClN3O2, the conformation about the N=C bond is E. Supramolecular chains propagated […]
4-[(E)-2-(2,4-Dichlorobenzylidene)hydrazin-1-yl]quinolin-1-ium chloride monohydrate
Authors: Wardell, S.M.S.V.; Tiekink, E.R.T.; Wardell, J.L.; Ferreira, M.L.; De Souza, M.V.N. Source: Acta Crystallographica. Section E, v. 68, p. 1232-1233, 2012. Publisher: International Union of Crystallography Abstract In the title hydrated salt, C16H12Cl2N3+·Cl–·H2O, there is a small twist in the cation as seen in the torsion angle linking the benzene ring to the rest of […]
7-Chloro-4-[(E)-2-(3,4,5-trimethoxybenzylidene)hydrazin-1-yl]quinoline
Authors: Ferreira, M.L.; De Souza, M.V.N.; De Souza, M.V.N.; Wardell, S.M.S.V.; Tiekink, E.R.T.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 68, p. 1214-1215, 2012. Publisher: International Union of Crystallography Abstract In the title compound, C19H18ClN3O3, the r.m.s. deviation through the 23 non-H and non-methoxy atoms is 0.088 Å, indicating a planar molecule with the exception […]