Authors: Rodrigues, F.A.R.; Bomfim, I.S.; Cavalcanti, B.C.; Pessoa, C.O.; Pinheiro, A.C.; Lima, C.H.S.; De Souza, M.V.N.
Source: European Chemical Bulletin, v. 3, p. 358-361-361, 2014.
Publisher: Deuton-X Ltd. by support of Research Centre for Natural Sciences, Hungarian Academy of Sciences.
Abstract
A series of fifty one pyrazinyl derivatives have been synthesized and evaluated for their activity against four cancer cell lines, exhibiting good citotoxicity (IC50 ranging from 1.1 to 5.6μg/mL). The structure-activity relationship (SAR) analysis indicated that the hydroxyl group located in ortho position is critical for the biological activity of these compounds. The presence of hydroxyl groups on benzene ring plays an important role in the anticancer activity of this series, feature especially observed in dissubstituted derivatives.Keywords: antitumor activity, pyrazinamide, hydrazones, drugs Document Type: Research Article DOI: None Publication date: 1 de Janeiro de 2014
