Biological evaluation of pyrazinamide derivatives as an anticancer class
Authors: Rodrigues, F.A.R.; Bomfim, I.S.; Cavalcanti, B.C.; Pessoa, C.O.; Pinheiro, A.C.; Lima, C.H.S.; De Souza, M.V.N. Source: European Chemical Bulletin, v. 3, p. 358-361-361, 2014. Publisher: Deuton-X Ltd. by support of Research Centre for Natural Sciences, Hungarian Academy of Sciences. Abstract A series of fifty one pyrazinyl derivatives have been synthesized and evaluated for their […]
Syntheses and Antimycobacterial Activities of [(2S,3R)-2-(Amino)-4- (Arenesulfonamido)-3-Hydroxy-1-Phenylbutane Derivatives.
Authors: Moreth, M.; Gomes, C.R.B.; Lourenço, M.C.; Soares, R.; Rocha, M.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J. Source: Medicinal Chemistry (Hilversum), v. 10, p. 189-200, 2014. Publisher: Bentham Science Abstract The syntheses of hydroxyethylsulfonamides, (2S,3R)-tert-butyl N-[4-(N-benzyl-4-R-phenylsulfonamido)-3- hydroxy-1-phenylbutan-2-yl]carbamates and (5) (2S,3R)-2-amino-4-[N-benzyl-4-R-benzenesulfonamido]-3-hydroxy-1- phenylbutane hydrochlorides (6), derived from (2S,3S)-Boc-phenylalanine epoxide, are reported. None of the compounds, […]
Mefloquine-Oxazolidine Derivatives: A New Class of Anticancer Agents
Authors: Rodrigues, F.A.R.; Bomfim, I.S.; Cavalcanti, B.C.; Pessoa, C.O.; Gonçalves, R.S.B.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N. Source: Chemical Biology & Drug Design (Print), v. 83, p. 126-131, 2014. Publisher: John Wiley & Sons, Inc. Abstract A series of 23 racemic mefloquine–oxazolidine derivatives, 4-[3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinolines, derived from (R*, S*)-(±)-mefloquine and arenealdehydes, have been evaluated […]
Synthesis and antitubercular evaluation of aryl substituted – 2 – oxazolines from L – amino acids
Authors: Souza, L.A.; Da Silva, E.T.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 2(5), p. 648-657, 2014. Publisher: Astucia Group Abstract This paper describes the synthesis and the in vitro antibacterial activity of a series of twelve substituted aryl-2-oxazolines against Mycobacterium tuberculosis. Seven compounds showed activity and two compounds exhibited a […]
