[:pb]Eco-Friendly and Highly Efficient Multigram Synthesis of N-(2-Hydroxyethyl)-2-Oxo-2H-Chromene-3-Carboxamide as a Useful Intermediate Using Sonochemistry[:]

[:pb]Authors: Pinto, L.; De Souza, M. V. N.
Source: Current Green Chemistry, v. 05, p. 104-107, 2018
Publisher: Bentham Science


This study describes a new, simple and efficient process for the preparation of N-(2- hydroxyethyl)-2-oxo-2H-chromene-3-carboxamide, on a multigram scale (0.38 moles), by using ultrasound irradiation as green chemistry method. Optimal conditions and yield (83%) were obtained by using 1.2 molar equivalents of ethanolamine at 675 W for 5.0 hours. This intermediate is very versatile and could be transformed in a wide range of derivatives, which could be employed in different areas, such as inorganic complexes, dyes, pesticides and fluorescent coumarins. In the medicinal chemistry, N-(2-hydroxyethyl)-2-oxo-2H-chromene-3-carboxamide is also very useful because a wide variety of compounds could be synthesized and evaluated with diverse types of diseases. In this context, it can be mentioned N-(2-chloroethyl)-2-oxo-2H-chromene-3-carboxamide, a useful intermediate, which was synthesized in this work in gram scale (0.04 moles) in 80% of yield, that could react with diverse types of nucleophiles.

Keywords: green chemistry, sonochemistry, ultrasound, multigram, coumarin, intermediate

Document Type: Research Article

DOI: 10.2174/2213346105666180528095426

Publication date: 2018


Compartilhar publicação


Deixe seu comentário


Sobre a SSCDT

Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.

posts Recentes