[:pb]Crystal Structure of the Chiral Azomethine Imine, (Z)-(S)-4-(tert-Butylcarbonylamino)-2-(2-methoxybenzylidene)-5-oxopyrazolidin-2-ium-1-ide, Obtained by the Cyclization of tert-Butyl (S)-2-[2-(methoxybenzylidene)hydrazine]-1-(hydroxymethyl)-2-oxocarbamate[:]
[:pb]Authors: Pinheiro, A. C.; De Souza, M. V. N.; Wardell, S. M. S. V.; Wardell, J. L. Source: Journal of Chemical Crystallography, v. 1, p. 1-8, 2018 Publisher: Springer Abstract Further study of the cyclization reactions of (S)-t-BuOCH2CONHCH(CH2OH)CONHN = Ar, derived from (L)-serine, has found that reaction with MeI/K2CO3 in Me2CO produces (Z)-(S)-4-(tert-butylcarbonylamino)-2-(benzylidene)-5-oxopyrazolidin-2-ium-1-ide, 3. We now wish to report […]
[:pb]In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06[:]
[:pb]Authors: Reis, P. A.; Pais, K. C.; Pereira, M. F.; Douradinha, B.; Costa, N. F.; Kaiser, C. R.; Bozza, P. T.; Areas, A. L. L.; Zalis, M. G.; Ferreira, M. L.; De Souza, M. V. N.; Frutuoso, V. S.; De Castro-Faria-Neto, H. C. Source: Parasitology Research, v. 117, p. 3585-3590, 2018 Publisher: Springer Abstract Antimalarial […]
[:pb]Crystal structures and Hirshfeld surfaces of four methoxybenzaldehyde oxime derivatives, 2-MeO- C H C=NOH ( = H and 2-, 3- and 4-MeO): different conformations and hydrogen-bonding patterns[:]
[:pb]Authors: Gomes, L. R.; De Souza, M. V. N.; Da Costa, C. F.; Wardell, J. L.; Low, J. N. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 74, p. 1553-1560, 2018 Publisher: Crystallographic Communications Abstract The crystal structures of four (E)-methoxybenzaldehyde oxime derivatives, namely (2-methoxybenzaldehyde oxime, 1, 2,3-dimethoxybenzaldehyde oxime, 2, 4-dimethoxybenzaldehyde oxime, 3, and 2,5-dimethoxybenzaldehyde oxime, 4, are discussed. The arrangements of […]
[:pb]Structural study of three heteroaryl oximes, heteroaryl-N=OH: Compounds forming strong C3 molecular chains[:]
[:pb]Authors: Low, J. N.; Wardell, J. L.; Da Costa, C. F.; De Souza, M. V. N.; Gomes, L. R. Source: European Journal of Chemistry, v. 9, p. 151-160, 2018 Publisher: European Journal of Chemistry Abstract In order to further investigate the structural chemistry of oximes and to further establish the main structural arrangements adopted, we have […]
[:pb]Different classical hydrogen-bonding patterns in three salicylaldoxime derivatives, 2-HO-4- C H C=NOH ( = Me, OH and MeO)[:]
[:pb]Authors: Gomes, L. R.; De Souza, M. V. N.; Da Costa, C. F.; Wardell, J. L.; Low, J. N. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 74, p. 1480-1485, 2018 Publisher: Science Direct Abstract The crystal structures of three salicyaldoxime compounds, namely 2-hydroxy-4-methylbenzaldehyde oxime, C8H9NO2, 1, 2,4-dihydroxybenzaldehyde oxime, C7H7NO3, 2, and 2-hydroxy-4-methoxybenzaldehyde oxime, C8H9NO3, 3, are discussed. […]
[:pb]Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis[:]
[:pb]Authors: Rufener, R.; Ritler, D.; Zielinski, J.; Dick, L.; Da Silva, E. T.; Araujo, A. S.; Joekel, D. E.; Czock, D.; Goepfert, C.; Moraes, A. M.; De Souza, M. V. N.; Müller, J.; Mevissen, M.; Hemphill, A.; Lundström-Stadelmann, B. Source: International Journal for Parasitology-Drugs and Drug Resistance, v. 8, p. 331-340, 2018 Publisher: Science Direct Abstract The cestode E. […]
[:pb]Synthesis, biological activity, and mechanism of action of 2-pyrazyl and pyridylhydrazone derivatives, new classes of antileishmanial agentes[:]
[:pb]Authors: De Souza, M. V. N.; Coimbra, E. S.; Antinarelli, L. M. R.; Crispi, M. A.; Nogueira, T. C. M.; Pinheiro, A. C. Source: ChemMedChem, v. 13, p. 1387-1394, 2018 Publisher: European Chemical Society Publishing Abstract In this work, we report the antileishmanial activity of 23 compounds based on 2-pyrazyl and 2-pyridylhydrazone derivatives. The compounds were tested against […]
[:pb]Eco-Friendly and Highly Efficient Multigram Synthesis of N-(2-Hydroxyethyl)-2-Oxo-2H-Chromene-3-Carboxamide as a Useful Intermediate Using Sonochemistry[:]
[:pb]Authors: Pinto, L.; De Souza, M. V. N. Source: Current Green Chemistry, v. 05, p. 104-107, 2018 Publisher: Bentham Science Abstract This study describes a new, simple and efficient process for the preparation of N-(2- hydroxyethyl)-2-oxo-2H-chromene-3-carboxamide, on a multigram scale (0.38 moles), by using ultrasound irradiation as green chemistry method. Optimal conditions and yield (83%) […]
[:pb]Lopinavir, an HIV-1 peptidase inhibitor, induces alteration on the lipid metabolism of Leishmania amazonensis promastigotes[:]
[:pb]Authors: Rebello, K. M.; Andrade-Neto, V. V.; Zuma, A. A.; Motta, M. C. M. ; Gomes, C. R. B.; De Souza, M. V. N.; Atella, G. C.; Branquinha, M. H.; Santos, A. L. S.; Torres-Santos, E. C.; D’avila-Levy, C. M. Source: Parasitology, v. 1, p. 1-7, 2018 Publisher: Cambridge University Press Abstract The anti-leishmania effects […]
[:pb]Expected and unexpected products of reactions of 2-hydrazinylbenzothiazole with 3-nitrobenzenesulfonyl chloride in different solventes[:]
[:pb]Authors: Morscher, A.; De Souza, M. V. N.; Wardell, J. L.; Harrison, W. T. A. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 74, p. 673-677, 2018 Publisher: Science Direct Abstract The syntheses and crystal structures of 2-[2-(propan-2-ylidene)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C10H12N2S+·C6H4NO5S−), (I), 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazole (C13H10N4O4S2), (II) and 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C13H11N4O4S2+·C6H4NO5S−), (III) are reported. Salt (I) arose from […]
[:pb] Synthetic aspects and first-time assessment of 2-amino-1,3-selenazoles against Mycobacterium tuberculosis[:]
[:pb]Authors: Facchinetti, V.; De Souza, M. V. N.; Nery, A. C. S.; Calixto, S. L.; T. Granato, J.; Coimbra, E. S.; Lourenco, M. C. S.; Gomes, C. R. B.; Vasconcelos, T. R. A. Source: Letters in Drug Design & Discovery, v. 15, p. 1224-1229, 2018 Publisher: Bentham Science Abstract Background: 2-aminoselenazoles became an important core […]
[:pb]Multicomponent Reactions in the Synthesis of Complex Fused Coumarin Derivatives[:]
[:pb]Authors: Pinto, L. S. S.; Couri, M. R. C.; De Souza, M. V. N. Source: Current Organic Synthesis, v. 15, p. 21-37, 2018 Publisher: Bentham Science Abstract Background: Coumarin is an important class of natural products with applications in different areas of knowledge. Due to its importance, several methodologies and strategies have been developed for […]
